Reducing the Risk of Cardiovascular Diseases in Community-dwelling Adults: an Ambispective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20,000
- 试验地点
- 2
- 主要终点
- Major adverse cardiovascular events
研究概览
简要总结
To establish and evaluate a new prediction model for assessing cardiovascular disease risk in community-dwelling adults.
详细描述
This is an ambispective, observational cohort study. In the retrospective part, we will enroll residents from Guangzhou or Foshan who participated in the annual health checks provided by the Chinese National Basic Public Health Service project between January 2015 and December 2019. The demographic characteristics, anthropometric measurements, laboratory assays, medical history, living habits, and medications will be collected through personal electronic health records obtained from the regional chronic disease management platform. In the prospective part, residents who participated in the annual health checks provided by the Chinese National Basic Public Health Service project after January 2020 will be enrolled. In addition to the data collected in the retrospective part, blood, urine and fecal samples and lifestyle questionnaires will be collected for further analysis. All participants will be followed-up till December 2025. A new prediction model for assessing cardiovascular disease risk will be established and evaluated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meet at least one of the following conditions:
- •Age ≥ 65 years;
- •Diabetes mellitus;
- •Hypertension;
排除标准
- •Refuse to provide informed consent;
结局指标
主要结局
Major adverse cardiovascular events
时间窗: 5 years
Major adverse cardiovascular events include all-cause mortality, acute myocardial infarction, coronary heart disease, heart failure and stroke.
次要结局
- Cognitive dysfunction(5 years)
- Atherosclerotic cardiovascular events(5 years)
- All-cause mortality(5 years)
- Renal functional deterioration(5 years)
- Renal replacement therapy and/or death due to acute renal failure(5 years)
- Incident atrial fibrillation(5 years)