Treatment of infertility with endometrial stem cells

Phase 1

Conditions: Recurrent implantation failure.

Registration Number: IRCT20210513051280N1

Lead Sponsor: Iranian academic center for education culture and research

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Female

Target Recruitment: 40

Inclusion Criteria

Women with recurrent implantation failure (Three unsuccessful embryo transfer cycles with transfer of at least one blast stage or one cleavage stage A in each cycle)
No history of previous pregnancy
FSH level of less than 10 mIU/mL
Negative results for HIV, HBS Ag, HCV and VDR

Exclusion Criteria

Hydrosalpinx
Stage 3 or 4 endometriosis
Asherman's syndrome
Endometrial organic disease
Chromosomal abnormalities in parents
Spermogram abnormalities (DFI more than 30 and Normal sperm morphology less than 2%
PCO with metabolic syndrome
Anti-phospholipid antibodies
Autoimmune diseases including rheumatoid arthritis, thyroid autoimmunity, lupus
History of cancer, chemotherapy or radiotherapy
Thin endometrium
History of immunosuppressive drug intake during the past three months

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Implantation rate. Timepoint: 2 weeks after embryo transfer. Method of measurement: Measurement of B-HCG.

Secondary Outcome Measures

Name	Time	Method
Clinical pregnancy rate. Timepoint: 6 weeks after embryo transfer. Method of measurement: Sonography.;Live birth rate. Timepoint: At the end of pregnancy period. Method of measurement: Parturition.;Twin pregnancy. Timepoint: 6 weeks after embryo transfer. Method of measurement: Sonography.;Newborn weight. Timepoint: After delivery. Method of measurement: Weighting.