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临床试验/NCT03727893
NCT03727893已完成不适用

Application of the WMS for Advanced Physical Training of Manual Wheelchair Users With Spinal Cord Injury

Washington University School of Medicine2 个研究点 分布在 1 个国家目标入组 14 人开始时间: 2018年10月22日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
14
试验地点
2
主要终点
VO2peak Change

研究概览

简要总结

The overall purpose of this pilot randomized control trial (RCT) is to determine the efficacy of the high-intensity interval training (HIIT) exercise protocols for the WheelMill System (WMS) to improve exercise intensity, cardiovascular fitness, metabolic health, and psychological well-being in manual wheelchair users (MWUs) with spinal cord injury (SCI).

详细描述

People with spinal cord injuries (SCI) are at greater health risk for major health conditions and poorer health outcomes than the population without disabilities. For people with SCI, physical activity is critical for both physiological and psychosocial well-being, however 75% of persons with SCI are not active enough to achieve activity-related health benefits. While current exercise guidelines for persons with SCI are limited and vary, health authorities and literature have focused more on recommendations for moderate-intensity exercise, however recent studies have shown that, due to the reduced exercise capacity of the active muscles used in persons with SCI, moderate-intensity exercise alone is inadequate to stimulate meaningful improvements in cardiovascular disease risk. An alternative exercise approach that has demonstrated significant reductions in cardiovascular disease risk and morality is high-intensity interval training (HIIT). Participating in exercise protocols of higher intensity may offer a more effective and time-efficient method of increasing cardiovascular fitness and metabolic health in persons with SCI. However, few studies have evaluated the efficacy of HIIT protocols to increase exercise intensity and clinically improve cardio metabolic health and fitness in this population. The WheelMill System (WMS) is a wheelchair roller-based system that allows persons with SCI to use their personal manual wheelchair for wheelchair training or endurance exercise. With this study, we aim to assess the efficacy of a HIIT intervention conducted on a wheelchair roller-based system in improving cardiorespiratory and metabolic function, psychosocial well-being, and exercise intensity for manual wheelchair users (MWUs) with SCI. We also aim to determine if the roller-based system is a feasible platform for delivering HIIT for MWUs with SCI as well as identifying the perspectives of the participants on the recruitment and enrollment process, the assessment methods, and tolerance and acceptance of the intervention protocol. The long-term goal of this research is to increase cardiorespiratory fitness and reduce cardiovascular and metabolic disease risk in MWUs. This study will serve as the initial step toward that goal by pilot testing a HIIT intervention to increase exercise intensity of MWUs with SCI to promote physiological and psychosocial activity-related health benefits. We will recruit, enroll, and randomize MWUs with SCI into a roller-based Intervention Group (IG) or the Control Group (CG). Participants in the IG will complete an initial exercise education session and a 12-week (3 sessions/wk) evidence-based HIIT program using the roller-based system. Participants in the CG will complete an initial exercise education session and enroll in a 12-week (3 sessions/wk) independent workout program at an accessible community-based fitness facility. This study will measure the potential physiological, functional, and psychosocial health benefits of participating in a HIIT program designed for MWUs with SCI. We will then use the findings to define how exercise training at a higher intensity can support health outcomes and improve therapeutic and community-based interventions to promote cardiorespiratory and metabolic health and well-being of people with SCI.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Participants will have a diagnosis of spinal cord injury (SCI)
  • be18 years or older
  • have the ability to self-propel a manual wheelchair (MWC) bilaterally with their upper extremities
  • use a MWC for at least 75% of their daily activities
  • participate in less than 60 minutes of moderate-intensity exercise per week in the last month
  • have written physician approval to participate in the study
  • understand English at a sixth-grade level or higher
  • be able to follow multi-step instructions
  • independently provide informed consent
  • be willing to participate in two assessments and 36 intervention sessions at the Enabling Mobility in the Community Laboratory (EMC Lab).

排除标准

  • maneuver MWC with their lower extremities or with only one upper extremity
  • have bilateral incoordination due to strength inequality or neurological involvement that impairs propulsion in a steady, straight line
  • have had surgeries compromising the integrity of the upper extremities or cardiovascular complications within the past year
  • currently receive medical treatment for an acute upper extremity injury
  • have a Stage IV pressure injury
  • are currently hospitalized
  • have a cognitive impairment that does not allow them to provide consent or follow multi-step directions.

结局指标

主要结局

VO2peak Change

时间窗: Baseline to Post Intervention at 4 months

VO2 peak will be measured using a standard computer-integrated, open-circuit, breath-by-breath metabolic measurement system (TrueOne 2400, Parvo Medics, Sandy, UT, US) while the participant performs a graded-exercise test on an ACE, SCIFIT PRO2 (Life Fitness, Tulsa, OK, US). In addition, an H7 Heart Rate Sensor (Polar Electro Inc., Lake Success, NY, US) will be placed on each participant to monitor heart rate during testing. Each participant will be fitted with a silicone mask to cover his or her mouth and nose while performing the exercise test, which is typically completed in 8-12 minutes depending on the participant's fitness level. The protocol involves a 3-minute warm-up at a workload of 8-10 watts (W) followed by a standard ACE ramp protocol. The ramp protocol requires participants to maintain 60 revolutions per minute (rpm) with incremental increases by 7 W every minute, until exhaustion.

The 6-minute Push Test (6MPT) Change

时间窗: Baseline to Post Intervention at 4 months

The 6MPT is a functional mobility and physical fitness test involving manual wheelchair users propelling a designated 30-meter loop. Participants are asked to propel as far as possible on the course within 6 minutes. Total distance propelled is determined by tallying the number of completed 30-meter loops and measuring the partially completed final lap using a tape measure.

次要结局

  • Weight Change(Baseline and Post Intervention at 4 months)
  • Leisure Time Physical Activity for People with Spinal Cord Injury (LTPAQ-SCI) Change(Baseline and Post Intervention at 4 months)
  • HbA1c Level Change(Baseline and Post Intervention at 4 months)
  • Body Composition Overall Body Fat % Change(Baseline and Post Intervention at 4 months)
  • BMI Change(Baseline and Post Intervention at 4 months)
  • Wheelchair Skills Test Questionnaire (WST-Q) Change(Baseline and Post Intervention at 4 months)
  • Wong-Baker FACES pain scale (FACES)(At baseline. During each intervention session. At follow up assessment.)
  • PROMIS-29 Profile (v2.0) Change(Baseline and Post Intervention at 4 months)
  • Wheelchair User's Shoulder Pain Index (WUSPI) Change(Baseline and Post Intervention at 4 months)
  • Cholesterol Change(Baseline and Post Intervention at 4 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Joseph Klaesner

Professor Program in Physical Therapy, Department of Radiology, Department of Biomedical Engineering

Washington University School of Medicine

研究点 (2)

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