Can Airflow Limitation in Chronic Obstructive Pulmonary Disease (COPD) be Reversible by Drugs?
Phase 4
Completed
- Conditions
- Chronic Obstructive Pulmonary Disease
- Interventions
- Drug: Macrolid, Theophylline, Inhaler Corticosteroids
- Registration Number
- NCT01010178
- Lead Sponsor
- Baqiyatallah Medical Sciences University
- Brief Summary
Critical combination of various approved drugs in management for patients suffering with COPD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
- current or past smoker COPD
Exclusion Criteria
- history of significant occupational or other environmental exposures or a connective tissue disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Macrolid, Theophylline, Corticosteroids Macrolid, Theophylline, Inhaler Corticosteroids Approved drug in this setting
- Primary Outcome Measures
Name Time Method 15% increasing in forced expiratory volume in 1 second 6 months
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie airflow limitation reversal in COPD by macrolids and theophylline?
How does the combination of macrolids, theophylline, and inhaled corticosteroids compare to standard COPD therapies in clinical outcomes?
Which biomarkers are associated with response to macrolid-theophylline-inhaler corticosteroid combinations in COPD patients?
What are the potential adverse events of long-term macrolid-theophylline-inhaler corticosteroid therapy in COPD management?
Are there alternative drug combinations targeting similar pathways as NCT01010178 for COPD treatment?
Trial Locations
- Locations (1)
Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Mollasadra St,
🇮🇷Tehran, Iran, Islamic Republic of
Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Mollasadra St,🇮🇷Tehran, Iran, Islamic Republic of