Anti-VEGF monotherapy versus combined anti-VEGF and end-point-management grid laser photocoagulation for diabetic macular edema - END-DME Study

niversity of Hong Kong, Nagoya City University Graduate school of Medical Sciences0 个研究点目标入组 200 人开始时间: 2015年6月5日最近更新: 2023年10月17日

研究概览

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•Macular edema is considered to be due to a cause other than diabetic macular edema. An ocular condition is present such that visual acuity loss would not improve from resolution of macular edema. Substantial cataract that is likely to be affecting visual acuity. Focal laser photocoagulation should be performed before enrolling into the study if needed. Three months gap required between last laser procedure and recruitment. History of panretinal (scatter) photocoagulation (PRP) within 3 months prior to enrollment. Anticipated need for PRP in the study period. History of major retinal surgery. History of YAG capsulotomy performed within 3 months. Aphakia. History of open-angle glaucoma. Exam evidence of external ocular infection. A subject is not eligible if any of the following exclusion criteria are present Significant renal disease, defined as a history of chronic renal failure requiring dialysis or kidney transplant. A condition that would preclude participation in the study. Major surgery within 28 days prior to randomization or major surgery planned during the next 6 months. Myocardial infarction, other cardiac event requiring hospitalization, stroke, transient ischemic attack, or treatment for acute congestive heart failure within 6 months prior to randomization. pregnant or lactating or intending to become pregnant within the next 12 months.

发起方

niversity of Hong Kong, Nagoya City University Graduate school of Medical Sciences