NCT03912922已完成不适用
SIT LESS 4: How Does Reducing Sitting Time Improve Glucose and Lipid Metabolism? A Study to Identify Underlying Mechanisms
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Insulin sensitivity
研究概览
简要总结
Research has shown that replacing sitting time with low intensity physical activity (such as slowly walking and standing) has beneficial effects on metabolic health, like insulin sensitivity, comparable to improvements after sitting all day in combination with 1h streneous exercise.
The main objective of this study is to investigate the underlying mechanisms responsible for improved insulin sensitivity after 4 days of sitting less compared to sitting and exercise in healthy obese women. Our secondary objective is to investigate the effects of sitting less on cardio metabolic parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Signed informed consent
- •Caucasian
- •Postmenopausal women
- •Aged 45-70 years at start of the study
- •Body mass index (BMI) 25 - 35 kg/m2
- •Stable dietary habits (no weight loss or gain >5kg in the past 3 months)
- •Sedentary lifestyle (not more than 2,5 hours of exercise per week in the past 3 months)
排除标准
- •Not able to complete the sitless try-out day according to the protocol
- •Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other)
- •No use of medication interfering with investigated study parameters (as determined by responsible physician)
- •Alcohol consumption of >2 servings per day
- •Smoking in the past 6 months
- •Participation in another biomedical trial which may have an effect on insulin sensitivity less than one month before the start of the study (screening visit)
- •Mental or physical disability which interferes with physical activity
- •Subjects with contra-indications for magnetic resonance imaging (MRI)
- •Reported participation in night shift work 2 weeks prior to the start of the study (screening visit) and during study participation. Night work is defined as working between midnight and 6.00 AM.
结局指标
主要结局
Insulin sensitivity
时间窗: Day 5 of intervention period
2-step hyperinsulinemic euglycemic clamp
次要结局
- substrate oxidation(Day 5 of intervention period)
- Intrahepatic lipid content(Day 5 of intervention period)
- Plasma cardio metabolic markers(Day 5 of intervention period)
- ex vivo skeletal muscle mitochondrial respiration(Day 5 of intervention period)
- Blood pressure(Day 5 of intervention period)
研究者
研究点 (1)
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