The Postoperative Iron in Cardiac Surgery (PICS-) trial:A randomised clinical trial comparing the efficacy of single-, high-dose intravenous iron and oral iron for the treatment of anaemia following cardiac surgery. - PICS-trial

Aarhus University Hospital0 个研究点目标入组 110 人开始时间: 2020年9月3日最近更新: 2023年10月3日

适应症

试验速览

暂无简介。

•1. Patients undergoing first-time, non-emergent cardiac surgery
•2. Moderate anemia on the first postoperative day (i.e. a haemoglobin concentration of = 5.0 mmol/l [8 g/dl] and < 6.8 mmol/l [11 g/dl])
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 50
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 60

•Absolute and relative contraindications to treatment with intravenous iron
•Treatment with intravenous iron within 4 weeks prior to surgery.
•Untreated vitamin B12 or folate deficiency.
•Anticipated inability to perform a six-minute walk test.
•Women of childbearing potential, pregnant and nursing women.
•Anticipated postoperative length of stay in the intensive care unit (ICU) > 48 hours.
•Patients incapable of giving consent personally.
•Significantly increased risk of non-adherence or loss to follow-up.
•Active participation in another interventional trial with potential impact on postoperative anaemia or exercise capacity.

发起方

Aarhus University Hospital