The role of nebulized sodium nitrite and argon on blood pressure and brain blood flow control

Phase 1

Recruiting

• Conditions: Hypertension; Cardiovascular - Hypertension; Stroke - Ischaemic

• Registration Number: ACTRN12622001330730
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-14
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Patients with essential hypertension (At least Stage 2 hypertension; untreated office systolic blood pressure (SBP) greater than or equal to 140 mmHg or diastolic blood pressure (DBP_ greater than or equal to 90 mmHg);
Patients with chronic atrial fibrillation, as established on ECG or Holter monitoring
Normotensive controls (office SBP less than or equal to 120 mmHg and DBP less than or equal to 80 mmHg);
Aged over 18 years;
Body mass index less than 35 kg/m2.

Exclusion Criteria

Hemodynamically significant valvular heart disease (excluding atrial fibrillation e.g., stenosis, mechanical valve replacement)
Severe left ventricular systolic dysfunction
Recent acute coronary syndrome (<12 months) (e.g., myocardiac infarction, angioplasty, unstable angina)
Previous coronary artery bypass surgery
Secondary causes of hypertension (e.g., phaeochromocytoma)
Recent stroke/transient ischaemic attack (<12 months)
Current smoker
Body mass index <18 kg/m2.
Current pregnancy
Current user of recreational drugs
Current abuser of alcohol
Inability to fully or appropriately provide consent (e.g., language issue, reading capability)
Underlying medical conditions, which in the opinion of the Investigator place the participant at unacceptably high risk for participating in the study.
Chronic and systemic illness including:
Severe respiratory disease (e.g., chronic obstructive pulmonary disease);
Severe, uncontrolled type II diabetes;
Current treatment for cancer or complete remission <5 years
Connective tissue or inflammatory disease
Neurological / psychiatric disease (e.g., peripheral neuropathy, dementia, Parkisnon’s, epilepsy)
Infection or pyrexial illness
Uncontrolled thyroid disorders
Renal impairment (e.g., glomerulus filtration rate less than 60)
Liver disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified