Vitamin A Kinetics and Mathematical Modeling in American Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Total traced vitamin A mass
研究概览
简要总结
Women were given a vitamin A tracer, and blood was sampled to determine individual and group vitamin A kinetics. Data were subsequently modeled using compartmental analysis to determine effects of study length on model outcomes.
详细描述
This is a longitudinal study in which American women were given an oral, stable isotope tracer of vitamin A, and blood was sampled in a staggered, serial design to determine individual and group vitamin A kinetics. Data were subsequently modeled using compartmental analysis, and study truncation analysis was performed on data to investigate the factor of study duration on resulting vitamin A kinetic models and outputs related to vitamin A metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 30 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI (18.5 - 24.9 kg/m2)
排除标准
- •Trying to become pregnant
- •Lactating
- •Weight loss > 4.5 kg during the past 3 months.
- •Actively trying to lose weight
- •Inability to refrain from drinking alcohol when requested
- •Amenorrhea
- •Acute or chronic illness including hepatitis
- •Current or previous history of anorexia or bulimia
- •Concurrent participation in other studies
- •Family member already enrolled in the study
研究组 & 干预措施
Vitamin A tracer
A stable isotope tracer of vitamin A was given orally.
干预措施: Vitamin A tracer (Other)
结局指标
主要结局
Total traced vitamin A mass
时间窗: Baseline through 152 days
Total amount of endogenous vitamin A determined by mathematical model, (µmol).
次要结局
- Compartmental model fractional transfer coefficients(Baseline through 152 days)
- Vitamin A disposal rate(Baseline through 152 days)
- Vitamin A tracer partitioning(Baseline through 152 days)
- Compartmental model complexity(Baseline through 152 days)
- Vitamin A equilibration time and partitioning(Baseline through 152 days)
- Vitamin A dietary intake(Baseline)
- Serum vitamin A half-life(Baseline through 152 days)