Molecular Taxonomy of Pediatric Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Cellular origins of relapse and the underlying epigenetic mechanisms associated with drug resistance
研究概览
简要总结
This laboratory study is looking into genes in samples from younger patients with relapsed acute lymphoblastic leukemia. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
详细描述
OBJECTIVES:
I. To identify global changes in the epigenome and various underlying histone modifications that characterize relapsed acute lymphoblastic leukemia (ALL).
II. To identify specific transcription factor-binding sites associated with histone alterations.
III. To correlate gene expression changes of differentially regulated genes at relapse with underlying chromatin modifications.
OUTLINE:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of B-cell acute lymphoblastic leukemia
- •Paired diagnosis-relapse primary patient samples obtained from the Children's Oncology Group (COG) cell bank
排除标准
- 未提供
结局指标
主要结局
Cellular origins of relapse and the underlying epigenetic mechanisms associated with drug resistance
时间窗: 1 month
Genes associated with histone modification
时间窗: 1 month
Biological pathways involved in relapse
时间窗: 1 month
次要结局
未报告次要终点