Screening for Risk Factors of Prediabetes Among Adult Patients at Sohag University Hospital
- Conditions
- PreDiabetes
- Interventions
- Diagnostic Test: HbA1cDiagnostic Test: lipid profileDiagnostic Test: CBCDiagnostic Test: Alb/cr ratioDiagnostic Test: serum creatinine .Diagnostic Test: CRPDiagnostic Test: urine analysisDiagnostic Test: ECGDiagnostic Test: fundus examination
- Registration Number
- NCT05864183
- Lead Sponsor
- Sohag University
- Brief Summary
* Prediabetes is an intermediate state of hyperglycemia with glycemic parameters above normal but below the diabetes threshold..
* during the average 3 years of follow-up Prediabetes is diagnosed based on laboratory tests: fasting plasma glucose level (100-125 mg/dl) ;HbA1c, (5.7-6.4%) or plasma glucose level after an oral glucose tolerance test ( 140-199 mg/dl).
* Reports estimate that more than 470 million people will have prediabetes by 2030.
* According to an expert panel of the American Diabetes Association, up to 70% of individuals with prediabetes will eventually develop diabetes.
* Observational evidence suggests as association between prediabetes and complications of diabetes such early nephropathy(10%) , small fiber neuropathy(18-25 %), early retinopathy (8-12%) and risk of macrovascular disease (52%) .
* Screening for prediabetes is designed to save lives or enhance an individual's quality of life by early detection so that screening will minimize the risk of developing diabetes or its complications .
- Detailed Description
* In this case control study we aim to screen for risk factors of prediabetes among adult patients to minimize the risk of developing diabetes or its complications .
* Prediabetes screening is also required to minimize medical costs such as hospitalization, outpatient care, surgery, medications, and laboratory test costs .
* Several studies had shown efficacy of lifestyle interventions in diabetes prevention by targeting obesity with increase in physical activity and dietary changes with a relative risk reduction of 40%-70% in adults with prediabetes ,also there is increasing evidence to prove the efficacy of pharmacotherapy in prevention of diabetes in adults with prediabetes
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 200
- Adult patient above 18 years old .
- all patients known to be diabetics .
- pregnancy .
- chronic depleting diseases,
- Those who were taking drugs known to influence blood glucose levels e.g. metformin, thiazolidinedione and steroids.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description control group HbA1c non prediabetic case group HbA1c prediabetic case group lipid profile prediabetic case group serum creatinine . prediabetic case group ECG prediabetic case group urine analysis prediabetic control group CBC non prediabetic control group serum creatinine . non prediabetic control group CRP non prediabetic control group urine analysis non prediabetic case group Alb/cr ratio prediabetic control group lipid profile non prediabetic control group Alb/cr ratio non prediabetic case group CBC prediabetic case group CRP prediabetic case group fundus examination prediabetic control group ECG non prediabetic control group fundus examination non prediabetic
- Primary Outcome Measures
Name Time Method comparison between the measurement of HbA1c in normal non prediabetics and prediabetics at Sohag university hospital . 6 months analysis of HbA1c measurements and compare the results in both groups
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sohag university hospital
🇪🇬Sohag, Egypt