A Comparative Study of Clonidine and Magnesium sulfate Premedication on peri operative hormonal stress responses, hemodynamic stability and postoperative analgesia in Laparoscopic Cholecystectomy
Recruiting
- Conditions
- Anesthetic management of patients with gallbladder diseases undergoing laparoscopic cholecystectomy .Anaesthesiology - AnaestheticsSurgery - Other surgery
- Registration Number
- ACTRN12616001233415
- Lead Sponsor
- South valley university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
American society of A nesthesiologists( ASA) I and II, patients with gallbladder diseases subjected for elective laparoscopic cholecystectomy( LC) .
Exclusion Criteria
Patients with cardiovascular,respiratory,renal, hepatic or neurological diseases, diabetes mellitus, pregnancy or breast feeding females, morbidly obese patients, endocrine disorders,prolonged procedures ( more than 120 minutes), patients on anti hypertensives, antipsychotics, analgesics or sedative medications
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hemodynamic stability(heart rate and mean arterial pressure) using ECG and sphygmomanometer respectively .[Baseline(before induction of general anesthesia), 3 minutes after endotracheal intubation, before pneumperitoneum, 15 minutes after pneumperitoneum, 30 minutes after pneumoperitoneum, 5 minutes after ex sufflation , 5 minutes after extubation and 2 hours postoperatively.];Level of cortisol and adrenocorticotrophic hormone(ACTH). <br>(This is a composite primary outcome) using serum assay.[Baseline( 30 minutes before transferring the patient to operative room), 3 minutes after endotracheal intubation,15 minutes after pneumoperitoneum, 5 minutes after exsuflation,2 hours after extubation and first postoperative day.]
- Secondary Outcome Measures
Name Time Method Postoperative analgesia[Pain is assessed using visual analogue score(VAS) at 2,4,6 ,8,10 and 12 hours postoperatively which is recorded on patient clinical charts by attending nurse.];Patient sedation. [Using Ramsay sedation score at pre-induction and 15 minutes after reaching PACU.]