COLLECTION OF DNA AND RNA FROM BREAST CANCER PATIENTS

Recruiting

• Conditions: breast cancer; 10006291

• Registration Number: NL-OMON34596
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

Participants have a confirmed diagnosis of breast cancer (any subtype).

Exclusion Criteria

see inclusion

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome measures will be the generation of comprehensive catalogues of<br /><br>genomic abnormalities for a minimum<br /><br>of 500 breast cancer samples by sequencing to high coverage depth both the<br /><br>cancer and matching normal genomes<br /><br>which will include identification of single nucleotide variants, insertions,<br /><br>deletions, copy number changes, translocations<br /><br>and other chromosomal rearrangements in conjunction with the generation of<br /><br>transcriptomic and epigenomic data sets<br /><br>using state*of*the*art approaches, such that most cancer genes mutated at 3% or<br /><br>greater prevalence will be identified.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>none</p><br>