Does the presence of antibodies to SARS-CoV-2 reduce the risk of subsequent COVID-19 in healthcare workers?

Not Applicable

• Conditions: COVID-19 (SARS-CoV-2 infection); Infections and Infestations

• Registration Number: ISRCTN11041050
• Lead Sponsor: Public Health England

Brief Summary

2020 Preprint results in https://doi.org/10.1101/2020.12.15.20247981 protocol (not peer reviewed) in preprint (added 08/01/2021) 2021 Preprint results in http://dx.doi.org/10.2139/ssrn.3790399 non-peer-reviewed results on efficacy of BNT162b2 mRNA vaccine in preprint (added 16/03/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35172051/ Protection from reinfection by previous infection or vaccination (added 17/02/2022) 2022 Protocol article in https://pubmed.ncbi.nlm.nih.gov/35768083/ (added 30/06/2022) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35858689/ results on incidence of, risk factors for, and impact of vaccines on primary SARS-CoV-2 infection during the second wave in England (added 21/07/2022) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36089104/ Nest case-control study investigating antibody correlates of protection (added 12/09/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-01-12
• Last Update Posted: 9 January 2023
• Study Completion: 2023-03-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 35768

Inclusion Criteria

Hospital healthcare worker willing to consent for regular follow up for 12 months with swabs and blood samples

Exclusion Criteria

Unwilling to participate in regular follow up

Study & Design

• Study Type: Observational
• Study Design: Not specified