Investigation of Psychophysiological Correlation of Aggression and Response to Aversive Stimuli
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 133
- 主要终点
- Heart Rate
研究概览
简要总结
This study investigates the psychophysiological correlations of aggression and response to aversive stimuli in a population of 133 children clinically diagnosed with conduct disorder (CD) and/or attention-deficit/hyperactivity disorder (ADHD). Data was gathered about participants' level of aggression through the Reactive-Proactive Aggression Questionnaire (RPQ). The stimuli that were presented to the participants included 1) a loud sound, 2) threatening photographs from the International Affective Picture System (IAPS), and 3) the Trier Social Stress Task (TSST). Participants' psychophysiological features of heart rate and galvanic skin conductance were measured and analyzed in relation to their RPQ scores and clinical diagnosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects between ages 7 and 16 years
- •Subjects who fulfil all criteria for a DSM-IV diagnosis of ADHD, conduct disorder, or oppositional defiant disorder
- •Subjects with willingness to participate in a randomized, double-blind controlled trial
- •Subjects with complete written, informed parental consent and child assent
- •Subjects with IQ of 70 or more
排除标准
- •Subjects who have IQ in the below 70
- •Subjects who are younger than 7 years old or older than 16 years old
- •Those without written parental consent
- •Those with brain pathology such as serious head injury, epilepsy, etc.
结局指标
主要结局
Heart Rate
时间窗: 7 minutes
For Trier Social Stress Task
Skin Conductance Response
时间窗: 4 minutes
For threatening photograph
次要结局
未报告次要终点
研究者
Jean Liu
Assistant Professor, Yale-NUS College and Adjunct Assistant Professor, Duke-NUS Graduate Medical School
Institute of Mental Health, Singapore