ong-term muscle protein synthesis in ICU patients
Not yet recruiting
- Conditions
- Sepsis, ICU-acquired weakness, muscle wasting,
- Registration Number
- NL-OMON24760
- Lead Sponsor
- Maastricht UMC+ (azM)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
1)Age >18 <75 years
2)Sepsis on admission (as defined by the Sepsis-3 criteria*)
Exclusion Criteria
1)Coagulation disturbances (not including use of anti-coagulants in prophylactic dosages)
2)Contraindication to enteral infusion (e.g. due to GI-tract perforation)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fractional synthesis rates (FSR) of muscle protein using muscle protein-bound and plasma 2H-alanine enrichments
- Secondary Outcome Measures
Name Time Method - changes in leg skeletal muscle mass (ultrasound of rectus femoris CSA) <br /><br>- urinary 3-methylhistidine concentrations <br /><br>- transcriptional changes of genes involved in muscle protein synthesis and breakdown