Comparative Evaluation of Demineralized Freeze-Dried Bone Allograft with and without fisetin gel in the treatment of Class II Furcation Defects: A Randomized Controlled Trial.

This study will include patients visiting the department of Periodontics and Implantology diagnosed with Stage III Periodontitis and exhibiting Class II furcation defects. Two sites in each patient will be assigned randomly for sampling.

It will be conducted in Department of Periodontics and Implantology, after receiving informed consent from the patient. All the clinical and radiographical parameters will be evaluated at baseline after which the sites in the patients will be randomly and equally divided into Test and Control groups to be treated with Fisetin gel with DFDBA and DFDBA alone respectively in Class II furcation defects in Stage III Periodontitis patients. The study will be initiated after clearance from the Institutional Ethics Committee. For each patient two sites will be randomly assigned as:

Group I: (Test Group) – Stage IIIPeriodontitis exhibiting Class II furcation defects to be treated with DFDBA with Fisetin gel**.**

Group II: (Control Group) - Stage IIIPeriodontitis exhibiting Class II furcation defects to be treated with DFDBA alone

Pre-surgical Hygiene Therapy

Initial therapy will consist of detailed oral hygiene instructions and Scaling and root planing. Prior to initiating the study, its purpose and design will be explained and written informed consent will be signed by every patient. The patients will be followed up after 21 days to assess oral hygiene status.

Surgical procedure: Under local anesthesia, full thickness mucoperiosteal flaps will be reflected and granulation tissue will be debrided. The root surfaces will be scaled and planed. In Group I the Class II furcation defects will be treated with DFDBA alone while in Group II the Class II furcation defects will be treated using DFDBA with Fisetin gel. The flaps will be sutured back to their original position. Periodontal dressing will be placed at the surgical sites.

Post-surgical Care: Patient will be placed on antibiotics and analgesics. Sutures will be removed after 7 days. Clinical results will be evaluated at 3 and 6 months post-operatively and radiographic evaluation will be performed at 6 months post-operatively by CBCT.