microRNAs Role in Pre-eclampsia Diagnosis
Completed
- Conditions
- Preeclampsia
- Registration Number
- NCT03562715
- Lead Sponsor
- Cairo University
- Brief Summary
Pre-eclampsia is one of the most threatening pregnancy complications. So far neither a secure, competent therapy for PE nor effective biomarkers for a premature discovery has been achieved.The aim of our study was to identify miRNAs 136, 494 and 495 genes expression in exosomes of peripheral blood compared to umbilical cord mesenchymal stem cells conditioned media released exososomes in patients with PE, as valuable markers for PE early prediction.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 200
Inclusion Criteria
To have an uncomplicated pregnancy:
- gestational age at venipuncture between 20 - 42 weeks
- no medical, obstetrical, or surgical complications
- absence of labor at the time of venipuncture
- delivery of a normal term (≥ 37 weeks) neonate whose birth weight was between the 10th and 90th percentile for gestational age
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Exclusion Criteria
Patients with chronic hypertension, renal disease, and fetuses affected with congenital anomalies were excluded
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The expression of miRNAs 136, 494 and 495 in exosomes of peripheral blood and UCMSCs conditioned media 2-3 months
- Secondary Outcome Measures
Name Time Method