Effect of oxygen administration on pulmonary vascular resistance and cardiac index in patients with chronic thromboembolic pulmonary hypertension. - Effect of oxygen administration on PVR and CI in CTEPH.

Department of Cardiology, Hospital Organization Okayama Medical Center0 个研究点目标入组 52 人开始时间: 2017年4月10日最近更新: 2023年10月17日

试验速览

阶段: 未知
状态: 已完成
发起方
入组人数: 52

研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

This study included 52 consecutive patients with CTEPH. Oxygen administration significantly decreased mean PAP by 3.8 mmHg ( p < 0.001) and pulmonary vascular resistance by 0.8 Wood units ( p < 0.001). Multivariate regression analysis identified baseline mean PAP as the only significant predictor of decreased mean PAP under oxygen administration. No significant difference in oxygen effect on mean PAP was found between patients with and without vasodilators.

研究设计

研究类型: Interventional

入排标准

年龄范围: 20years-old 至 ot applicable（—）
性别: All

入选标准

未提供

排除标准

•1) Patients with ischemic heart disease. 2) Patients with severe systemic hypertension (systolic blood pressure higher than or equal to 180 mmHg and/or diastolic blood pressure higher than or equal to 110 mmHg). 3) Pregnant patients. 4) Patients with severe valvular heart disease. 5) Patients with a history of acute myocardial infarction and/or cerebral vascular disease within 6 months. 6) Patients with hypotension (systolic blood pressure lower than or equal to 85mmHg). 7) Patients with severe ventricular arrhythmia. 8) Patients with severe renal dysfunction (Serum creatinine higher than or equal to 2mg/dl). 9) Patients with severe liver dysfunction. 10) Patients with chronic inflammatory disease. 11) Patients with malignancy. 12) Patients who were considered as inadequate for enrollment by the principal investigator.

研究者

发起方

Department of Cardiology, Hospital Organization Okayama Medical Center

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