Effect of oxygen administration on pulmonary vascular resistance and cardiac index in patients with chronic thromboembolic pulmonary hypertension.
- Conditions
- chronic thromboembolic pulmonary hypertension.
- Registration Number
- JPRN-UMIN000026882
- Lead Sponsor
- Department of Cardiology, Hospital Organization Okayama Medical Center
- Brief Summary
This study included 52 consecutive patients with CTEPH. Oxygen administration significantly decreased mean PAP by 3.8 mmHg ( p < 0.001) and pulmonary vascular resistance by 0.8 Wood units ( p < 0.001). Multivariate regression analysis identified baseline mean PAP as the only significant predictor of decreased mean PAP under oxygen administration. No significant difference in oxygen effect on mean PAP was found between patients with and without vasodilators.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 52
Not provided
1) Patients with ischemic heart disease. 2) Patients with severe systemic hypertension (systolic blood pressure higher than or equal to 180 mmHg and/or diastolic blood pressure higher than or equal to 110 mmHg). 3) Pregnant patients. 4) Patients with severe valvular heart disease. 5) Patients with a history of acute myocardial infarction and/or cerebral vascular disease within 6 months. 6) Patients with hypotension (systolic blood pressure lower than or equal to 85mmHg). 7) Patients with severe ventricular arrhythmia. 8) Patients with severe renal dysfunction (Serum creatinine higher than or equal to 2mg/dl). 9) Patients with severe liver dysfunction. 10) Patients with chronic inflammatory disease. 11) Patients with malignancy. 12) Patients who were considered as inadequate for enrollment by the principal investigator.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method