The Prognostic Value of Troponin T for Long-term Outcome After Cardiac Surgery
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 3,000
- Locations
- 1
- Primary Endpoint
- Death and/or major adverse cardiac events
Study Overview
Brief Summary
This survey has two aims. First, we would like to be informed about the health condition of our patients two years following heart surgery at University Hospital, Basel. Second, we are interested in determining whether a patient's long-term outcome can be predicted by the analysis of blood samples taken shortly after heart surgery.Troponin T, the blood parameter that we are interested in, is routinely assessed in the Intensive Care Unit. The purpose of this survey is to determine whether or not it is also possible to infer the long-term outcome from this blood parameter.
Detailed Description
Hypothesis and purpose:
The primary hypothesis of this study is that the amount of troponin T release after cardiac surgery is associated with mortality and cardiac morbidity within 1 year after surgery. Patients undergoing coronary procedures using cardiopulmonary bypass (CPB) (i.e., CABG, valvular and combined on-pump procedures) will be analysed.
A further purpose of the study is to evaluate the outcome of patients undergoing cardiac procedures at our institution, as this is currently not quantified.
Study design:
After ethical approval, we will conduct our study in two parts. In the first part, we will perform a retrospective cohort study at the University Hospital Basel to assess the 1 year outcome in all patients who have undergone cardiac surgery at our institution between January 1, 2005 and December 31, 2006. In addition, we will identify the best cut-off value of postoperative troponin T for predicting morbidity and mortality 1 year after open-heart surgery.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 16 Years to — (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •On-pump cardiac surgery at University Hospital of Basel
Exclusion Criteria
- •Off-pump cardiac surgery
- •Procedures requiring hypothermic cardiocirculatory arrest
Outcomes
Primary Outcomes
Death and/or major adverse cardiac events
Time Frame: 12 months after cardiac surgery
Secondary Outcomes
No secondary outcomes reported