Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than Infertility

Completed

• Conditions: Varicocele
• Interventions: Procedure: Microsurgical subinguinal varicocelectomy

• Registration Number: NCT02006316
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The purpose of this study is to evaluate whether clinical varicoceles are associated with abnormal semen parameters and whether varicocelectomy could improve the semen parameter in patients unrelated with infertility.

Detailed Description

While most studies are continued to validate the observations of significant improvements in sperm density and motility after varicocele ligation in infertile patients, there have been few studies to investigate the effects of varicocelectomy on semen parameters in adult men unrelated with infertility. The purpose of this study was to determine whether varicocelectomy could improve the semen parameter of these patients as well as whether clinical varicoceles are associated with abnormal semen parameters in patients unrelated with infertility.

Study Timeline

• Study Start: 2000-01
• Primary Completion: 2008-04
• Study Completion: 2010-03
• Study First Submitted: 2010-03-17
• Study First Submitted QC: 2013-12-04
• Study First Posted: 2013-12-10
• Status Verified: 2014-05
• Last Update Submitted: 2014-05-13
• Last Update Posted: 2014-05-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 121

Inclusion Criteria

• men with clinical varicoceles underwent microsurgical varicocelectomy due to causes other than infertility such as testicular pain, discomfort or scrotal mass

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Exclusion Criteria

• adolescents
• men with proven fertility or azoospermia
• men with preoperative normal sperm analysis
• available data to compare between preoperative and postoperative semen analyses

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
varicoceles	Microsurgical subinguinal varicocelectomy	men with clinical varicoceles underwent microsurgical varicocelectomy due to causes other than infertility such as testicular pain, discomfort or scrotal mass

Primary Outcome Measures

Name	Time	Method
Sperm concentration, motility, and morphology	at postoperative 4months	To observe the change of sperm concentration, motility, and morphology pre and postoperatively in the patients of inclusion criteria

Secondary Outcome Measures

Name	Time	Method
whether semen analysis should be done in men with clinical varicocele regardless of the chief complaint	at postoperative 4months	this result would show the need of performing semen analysis even in the patients with clinical varicocels due to causes other than infertility

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of