Water Intake and Glycemic Response : Preliminary Study

Not Applicable

• Conditions: Healthy
• Interventions: Other: Glucose Ref and 450 ml water; Other: Glucose Ref - Std; Other: White Bread with 250 ml water; Other: White Bread and 700 ml water; Other: White Bread with 125 ml water (twice)

• Registration Number: NCT02625363
• Lead Sponsor: Nutrifood Research Center, Jakarta, Indonesia

Brief Summary

Glycemic index concept is widely used to determine impact of a food to blood glucose. Several studies showed that water content and intake after meal may influence glycemic response of the meal and thus have an effect on the result of GI measurement. Currently these studies found conflicting results. Therefore, this study aims to determine whether water intake, specifically after meal, may influence the glycemic response and glycemic index value of the meal.

Detailed Description

Glycemic index methods are performed according to Food and Agricultural Organization/WHO recommendations.

Study Timeline

• Study Start: 2015-11
• Study First Submitted: 2015-11-16
• Status Verified: 2015-12
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Study First Submitted QC: 2015-12-04
• Last Update Submitted: 2015-12-04
• Study First Posted: 2015-12-09
• Last Update Posted: 2015-12-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Age between 20-40 years
• fasting blood glucose 70-99 mg/dL
• Indonesians

Exclusion Criteria

• having diabetes
• smoking
• if women, pregnant or lactating
• being allergic to food used in this study
• having gastrointestinal disturbance
• in regular medication
• refusal to sign the consent form

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Glucose Ref and 450 ml water	Glucose Ref and 450 ml water	250 ml glucose solution with 50 gram available carbohydrate per serving. Sample was consumed with additional water intake @150 ml at 45, 75, and 105 minutes after meal consumption
Glucose Ref - Std	Glucose Ref - Std	250 ml glucose solution with 50 gram available carbohydrate per serving, used as reference
White Bread with 250 ml water	White Bread with 250 ml water	White bread with 50 gram available carbohydrate was consumed with 250 ml water immediately after meal consumption
White Bread and 700 ml water	White Bread and 700 ml water	White bread with 50 gram available carbohydrate was consumed with 250 ml water immediately after meal consumption. Moreover, subjects given additional water intake @150 ml at 45, 75, and 105 minutes after meal consumption
White Bread with 125 ml water (twice)	White Bread with 125 ml water (twice)	Sample consumed with 125 ml water immediately after meal consumption, and additional 125 ml water after 60 minutes

Primary Outcome Measures

Name	Time	Method
2 h postprandial blood glucose level (Glycemic Response)	fasting 0 min, 15 min, 30 min, 45 min, 60 min, 90 min, 120 min
Glycemic index value of meal (white bread)	fasting 0 min, 15 min, 30 min, 45 min, 60 min, 90 min, 120 min	The glycemic index is a calculated from measurements of area under the glucose curve after the food is eaten, divided by the corresponding area after the control food is eaten. The value is multiplied by 100 to represent a percentage of the reference food.

Trial Locations

Locations (1)

PT Nutrifood Indonesia; 🇮🇩 Jakarta, DKI Jakarta, Indonesia