Human Specimen Collection to Support Basic and Clinical Research
Overview
- Phase
- N/A
- Intervention
- Group1
- Conditions
- Sickle Cell Disease
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
- Enrollment
- 2000
- Locations
- 2
- Primary Endpoint
- evaluating the role of nitric oxide, inflammatory mediators, and endothelial function in inflammatory diseases of the vasculature such as sickle cell disease, coronary artery disease, pulmonary vascular or advanced lung disease, malaria, and sep...
- Status
- Enrolling by Invitation
- Last Updated
- 2 months ago
Overview
Brief Summary
The collection of human specimens from both patients and healthy volunteers is necessary for the development of laboratory assays to further basic and clinical research studies. This protocol defines the purposes for which specimens will be collected and establishes general conditions under which sample collection will be performed.
Detailed Description
The collection of human specimens from both patients and healthy volunteers is necessary for the development of laboratory assays to further basic and clinical research studies. This protocol defines the purposes for which specimens will be collected and establishes general conditions under which sample collection will be performed.
Investigators
Eligibility Criteria
Inclusion Criteria
- •INCLUSION CRITERIA:
- •Males or females of age 18 years and older can be included in the study.
Exclusion Criteria
- •Individuals without sickle cell disease or other chronic anemias who wish to donate blood will be excluded if the hemoglobin is less than 10 g/dL for women or less than 12g/dL for men.
- •Individuals with sickle cell disease or other chronic anemias will be excluded from donating blood samples if the hemoglobin is less than 6 g/dL.
- •A participant s most recent CBC result, obtained in the past 12 months, will be used to determine eligibility.
- •There are no exclusion criteria for participants donating urine.
Arms & Interventions
Group1
Clinical Center Patients, Healthy Volunteers
Outcomes
Primary Outcomes
evaluating the role of nitric oxide, inflammatory mediators, and endothelial function in inflammatory diseases of the vasculature such as sickle cell disease, coronary artery disease, pulmonary vascular or advanced lung disease, malaria, and sep...