Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy

Not Applicable

Recruiting

• Conditions: Takotsubo Cardiomyopathy

• Registration Number: NCT04513054
• Lead Sponsor: University of Aberdeen

Brief Summary

Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. In the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. This could also have implications for their families.

Detailed Description

Acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. Despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. The researchers propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. The investigators will also archive DNA for identification of future candidate genetic variants. Ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward.

Study Timeline

• Study Start: 2019-03-12
• Study First Submitted: 2020-08-03
• Study First Submitted QC: 2020-08-11
• Study First Posted: 2020-08-14
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-18
• Last Update Posted: 2024-12-24
• Primary Completion: 2028-12-31
• Study Completion: 2028-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 700

Inclusion Criteria

• All patients who have been diagnosed with Takotsubo cardiomyopathy in Scotland between 2010 to date.
• Familial cases elsewhere in the world who would be willing to participate.

Exclusion Criteria

• Unwillingness to participate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Genome Wide Association Study	At baseline	Genome Wide Association Study to search for susceptibility variants

Trial Locations

Locations (1)

Cardiovascular Research Facility; 🇬🇧 Aberdeen, Aberdeenshire, United Kingdom