Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy
- Conditions
- Takotsubo Cardiomyopathy
- Interventions
- Genetic: Blood collection for genetic analysis
- Registration Number
- NCT04513054
- Lead Sponsor
- University of Aberdeen
- Brief Summary
Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. In the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. This could also have implications for their families.
- Detailed Description
Acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. Despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. The researchers propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. The investigators will also archive DNA for identification of future candidate genetic variants. Ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 700
- All patients who have been diagnosed with Takotsubo cardiomyopathy in Scotland between 2010 to date.
- Familial cases elsewhere in the world who would be willing to participate.
- Unwillingness to participate
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Takotsubo Case Arm Blood collection for genetic analysis A patient that has been diagnosed with Takotsubo Cardiomyopathy from 2010 onwards.
- Primary Outcome Measures
Name Time Method Genome Wide Association Study At baseline Genome Wide Association Study to search for susceptibility variants
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Cardiovascular Research Facility
🇬🇧Aberdeen, Aberdeenshire, United Kingdom