A clinical study to investigate the molecular effects of remote ischemic preconditioning in the myocardium of CABG patients with or without diabetes mellitus
- Conditions
- coronary artery bypass grafting1001108210007593
- Registration Number
- NL-OMON33897
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 56
Inclusion Criteria
>18 years, elective CABG surgery (with or without aortic valve surgery), written informed consent.
Exclusion Criteria
<18 years, emergency operations, pregnancy, severe COPD, absent informed consent, SaO2<90% at room temperature, presumed non-cooperatives, legal incapacity, renal failure, liver failure
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Main study parameters are expression of signalling pathway proteins, detected<br /><br>by molecular analysis from myocardial probes taken before and after RIPC<br /><br>protocols during CABG surgery. ( PKC-*, p38MAPK, ERK and HSP27). </p><br>
- Secondary Outcome Measures
Name Time Method <p>Ee will investigate standard hemodynamic parameters obtained during standard<br /><br>cardiac surgery.<br /><br></p><br>