Influence of High Intensity Exercise on Insulin Resistance, Muscle Contractile Properties, Aerobic Capacity and Body Composition in Multiple Sclerosis

Not Applicable

Completed

• Conditions: Multiple Sclerosis; Healthy Controls
• Interventions: Behavioral: Training

• Registration Number: NCT01845896
• Lead Sponsor: Bert Op't Eijnde

Brief Summary

The purpose of this study is to investigate the effects of a combined training programme and a high intensity interval training programme on insulin resistance, muscle strength/ muscle contractile properties, aerobic capacity and body composition in MS patients.

It is assumed that the the above mentioned clinical parameters will improve due to physical exercise.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-04-30
• Study First Submitted QC: 2013-04-30
• Study First Posted: 2013-05-03
• Primary Completion: 2014-03
• Study Completion: 2014-03
• Status Verified: 2014-05
• Last Update Submitted: 2014-05-03
• Last Update Posted: 2014-05-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Diagnosed MS according to the McDonald criteria
• Expanded Disability Status Scale (EDSS) between 0.5 and 6
• Be able to train 5 times in 2 weeks at the University

Exclusion Criteria

• Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases (like diabetes type 2)
• Having had an relapse in a period of 3 months prior to the start of the intervention period
• Having an relapse during the intervention period
• Pregnancy and other contra indications for physical activity
• Mental disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Combined exercise	Training	12 weeks combined exercise programme (supervised)
High intensity interval training	Training	12 weeks high intensity interval exercise programme (supervised)

Primary Outcome Measures

Name	Time	Method
insulin sensitivity (insulin profile)	change from baseline to 12 weeks	glucose and insulin concentration measurements in blood
muscle contractile properties	from baseline to 12 weeks	measurements of cross sectional area and fiber distribution in muscle fibers of the m. vastus lateralis + measurements of enzymatic reactions, ATP, glycogen, ...

Secondary Outcome Measures

Name	Time	Method
muscle strength of knee extensor/flexor	change from baseline to 12 weeks	by means of an isokinetic dynamometer the muscle strength and endurance will be measured
body composition	Change from baseline to 12 weeks	Weight, body fat% and lean tissue% will be assessed by means of a DEXA scan
aerobic capacity	change from baseline to 12 weeks	by means of a submaximal endurance test (ergometer)
cytokine profile	change from baseline to 12 weeks	measurements of blood cytokine levels
Self-reported measures	Change from baseline to 12 weeks	The self-reported measures contains some questionnaires

Trial Locations

Locations (1)

Reval; 🇧🇪 Diepenbeek, Belgium