Ciculating endothelial cells in Preeclampsia

Completed

• Conditions: preeclampsia; 10010273

• Registration Number: NL-OMON32080
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Case group:
- diagnosis of severe preeclampsia based upon the ACOG criteria
- written informed consent
Control group:
- ASA class I pregnant patients visiting our out-patient clinic
- written informed consent

Exclusion Criteria

Control group:
- ASA class II or more
- previous pregnancies with placental syndromes as preeclampsia, growth retardation and/or gestational diabetes
- placental syndrome during the index pregnancy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameter:<br /><br>CEC levels in patients with severe preeclampsia</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters<br /><br>- To analyze the relation of CEC levels with organ damage and dysfunction.<br /><br>- To analyze the relation of CEC levels with clinical parameters as<br /><br>bloodpressure and proteinuria.<br /><br>- Correlation between CEC levels and levels of circulating thrombomodulin and<br /><br>other soluble markers like endoglin and e-selectin.</p><br>