A Prospective, Multicenter,Registry Study of Aortic Valve Stenosis in Zhejiang Elderly
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Valvular Heart Disease
- Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Enrollment
- 1
- Locations
- 1
- Primary Endpoint
- All-cause mortality,disabling strokes and Surgical or transcatheter aortic valve replacement
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
Aortic valve stenosis (AVS) is becoming more and more frequent with the aging, which has brought a heavy burden to the world. However, the prevalence and prognosis of valvular heart disease are not so clear, especially in the developing countries such as China etc. Because of the slow and progressive nature of AVS, symptoms might not be too severe to be diagnosed on time. Our retrospective survey (Int J Cardiol. 2016 Nov 25) indicated that severe aortic valve stenosis are very common in China. Hence, we design a prospective, observational cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective ,treatments and prognosis of Chinese elderly patients with aortic valve stenosis.
Investigators
Jian'an Wang,MD,PhD
President of Second Affiliated Hospital, School of Medicine, Zhejiang University & Chief of Cardiology
Second Affiliated Hospital, School of Medicine, Zhejiang University
Eligibility Criteria
Inclusion Criteria
- •Patients over 60 years old meet the following condition moderate or above aortic stenosis as defined by echocardiography: Aortic stenosis, moderate or above, or valve area≤1.5cm2, or maximal jet velocity ≥3.0m/sec, or mean pressure gradient≥20mmHg
Exclusion Criteria
- •Patients cannot be followed up for any reasons.
- •Patients in critical condition may be die in one year.
- •Patients have been enrolled in this study.
Outcomes
Primary Outcomes
All-cause mortality,disabling strokes and Surgical or transcatheter aortic valve replacement
Time Frame: one year
time from enrolled to first occurrence of any of the components of the composite outcome
Secondary Outcomes
- Surgical or transcatheter aortic valve replacement(one year)
- Hospitalization for heart failure(one year)
- Cardiovascular death(one year)