Clinical evaluation of the addition of antifungal drugs to denture liner material in the treatment of oral candidiasis

Not Applicable

• Conditions: Candida; Upper Complete Denture; Denture Stomatitis; C01 Infecções

• Registration Number: RBR-9yjjxvq
• Lead Sponsor: Karin Hermana Neppelenbroek

Brief Summary

The smears of the palates in the groups Experimental Nystatin and Chlorhexidine did not show mycelial Candida (0%) at the end of 14 days of treatment and, after 60 days of follow-up, only 1 patient of group Experimental Chlorhexidine presented its presence, and these results were better than the Antifungal Control (P less than 0.05). There was a significant reduction in the mycelial form scores in the denture smears for all study groups at the end of the treatment (day 14) (P less than 0.05), but this difference was maintained for up to 60 days of follow-up only for the groups in which the upper complete denture were relined (Reline Control and Experimental Nystatin and Chlorhexidine) (P less than 0.05). Compared to the baseline ( day 0), only mycological cultures from palates of group Experimental Nystatin and those from dentures of groups Experimental Nystatin and Chlorhexidine showed a significant reduction in the values of colony forming units per milliliter after 14 days of treatment, and these results were maintained for up to 60 days of follow-up (P less than 0.05). Patients in the control groups (Antifungal and Reline) did not show clinical improvement in the denture stomatitis severity at the end of treatment (day 14) (P greater than 0.05), which was observed only significantly for groups Experimental Chlorhexidine and Nystatin, statistically maintained in all follow-up periods (P less than 0.05). Regarding predisposing factors, it was suggested for the sample of patients selected for this study that denture stomatitis may be related to senility, xerostomia, use of antihypertensive drugs, female gender, nocturnal use of upper complete denture, poor habits of denture hygiene and upper complete denture age above 5 years.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-05-31
• Study Start: 2022-03-21
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Volunteer users of conventional removable upper denture; clinical diagnosis for denture stomatitis in the palatal mucosa supporting the complete denture, both genders, any age, regardless of the condition of the mandibular arch and the use and status of the lower denture.

Exclusion Criteria

Volunteers with anemia; immunocompromised; with uncontrolled endocrinopathologies; in a therapeutic regimen with antibiotics, steroids or antifungals in the last three months; under antineoplastic treatment by radio or chemotherapy; users of the same upper complete denture for over 30 years

Study & Design

• Study Type: Intervention
• Study Design: Not specified