Periodontal Disease Prevention Study:A Retrospective Cohort Study to Assess the Effect of Genetics and Dental Preventive Care on Periodontal Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5,117
- 试验地点
- 1
- 主要终点
- Percentage of Participants With Tooth Loss Over 16 Year Period
研究概览
简要总结
This study is one component of a program to improve the maintenance of good dental health and the prevention of disease by use of risk stratification methods to efficiently guide increased preventive services to adult dental patients who are at increased risk for the major dental diseases, caries and adult periodontitis.
The investigators will use a retrospective cohort model to analyze a large dental claims database to determine if the frequency of preventive services influenced the periodontal disease outcomes and to determine if periodontal risk assessment information can be used to stratify dental patients into "high risk" and "low risk" categories that influence the effect of preventive services on periodontitis outcomes.
Primary Objective To evaluate whether dental patients who are classified as "low risk" for periodontal disease progression, based on history of periodontitis (claims history), smoking, diabetes, and IL-1 genetic variations, have different primary and secondary endpoints if they had two dental cleanings per year compared to one cleaning per year.
Secondary Objectives To evaluate whether dental patients who are classified as "high risk" for periodontal disease progression, based on a history of periodontitis, smoking, diabetes, and IL-1 genetic variations, have different primary and secondary endpoints if they had two dental cleanings per year compared to one cleaning per year.
To evaluate whether dental patients who have had one dental cleaning per year have different primary and secondary endpoints if they are classified as "low risk" for periodontal disease compared to patients who are classified as "high risk." To evaluate whether dental patients who have had two dental cleaning per year have different primary and secondary endpoints if they are classified as "low risk" for periodontal disease compared to patients who are classified as "high risk."
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 34 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Study may include all participants who are 34-55 years old in 1992 (48-68 years old in 2010) and who have at least a 15-year dental claim history with Delta Dental.
排除标准
- •Organ transplant recipients are excluded.
结局指标
主要结局
Percentage of Participants With Tooth Loss Over 16 Year Period
时间窗: 16 years
Tooth loss rate over 16 years was calculated as the cumulative percentage of participants with tooth loss over 16 years.
次要结局
- Change in Total Periodontal Claims During the Monitoring Period(10 and 15 years)
- Change in Periodontal Surgery Claims(10 and 15 years)
- Change in Total Dental Claims During Monitoring Period(10 and 15 years)
- Change in Relationship of Risk Category & Tooth Loss Rate With Systemic Disease History on Questionnaire.(10 and 15 years)
- Change in Evaluation for Dental Caries and Oral Cancer Within the Risk Categories(10 and 15 years)
研究者
William Giannobile
Principal Investigator
University of Michigan