Risk Factors for Predictors of MACEs After RA-CABG

Completed

• Conditions: Coronary Artery Disease

• Registration Number: NCT04935086
• Lead Sponsor: Ruijin Hospital

Brief Summary

As the secondary choice of artery grafts, radial artery is more and more used to achieve multiple arterial revascularization in CABG. Risk factors for predictors of major cardiovascular adverse events (MACE) after CABG using radial-artery grafts (RA-CABG), however, remain uncertain. This case-control study aims to identify the baseline predictors of MACE after RA-CABG.

We will collect the baseline characteristics and perioperative data of patients underwent RA-CABG from Jan. 2009 to Dec. 2019 in our single center. By reviewing the latest follow-up records, we will examine the correlation between the baseline characteristics and clinical outcomes (MACEs), then identify the independent risk factors for predictors of MACEs after RA-CABG.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-06-03
• Study First Submitted QC: 2021-06-15
• Study First Posted: 2021-06-22
• Study Start: 2021-06-30
• Primary Completion: 2021-11-30
• Study Completion: 2021-11-30
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-07
• Last Update Posted: 2024-12-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 370

Inclusion Criteria

• Underwent CABG using at least a radial artery grafts from Jan.2009 to Dec.2019. with or without cardiopulmonary bypass , with or without concomitant procedure
• Aged 18 and above at procedure
• With any gender

Exclusion Criteria

• With unavailable medical records

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
7-day MACE-4	7 days post-CABG	a composite of all-cause death, myocardial infraction, stroke and repeat revascularization
30-day MACE-4	30 days post-CABG	a composite of all-cause death, myocardial infraction, stroke and repeat revascularization
1-year MACE-4	1 year post-CABG	a composite of all-cause death, myocardial infraction, stroke and repeat revascularization
3-year MACE-4	3 years post-CABG	a composite of all-cause death, myocardial infraction, stroke and repeat revascularization

Secondary Outcome Measures

Name	Time	Method
MACE-3	7 days, 30 days, 1 year, and 3 years post-CABG	a composite of CV-death, myocardial infraction and stroke
All-cause death	7 days, 30 days, 1 year, and 3 years post-CABG	Death from any cause
CV-death	7 days, 30 days, 1 year, and 3 years post-CABG	Including death resulting from an acute myocardial infarction , sudden cardiac death, death due to heart failure, death due to stroke, death due to cardiovascular procedures, death due to cardiovascular hemorrhage, and death due to other cardiovascular causes
Myocardial infraction	7 days, 30 days, 1 year, and 3 years post-CABG	According to the 2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials, including CABG-related MI, non CABG-related MI, silent MI and unknown type.
Stroke	7 days, 30 days, 1 year, and 3 years post-CABG	According to the 2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials, including ischemic, hemorrhagic and unknown type.
Repeat revascularization	7 days, 30 days, 1 year, and 3 years post-CABG	According to the 2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials, including any PCI and CABG.

Trial Locations

Locations (1)

Ruijin Hospital Shanghai Jiao Tong University School of Medicine; 🇨🇳 Shanghai, Shanghai, China