NCT01804283UnknownNot Applicable
Effects of Ischemic Postconditioning on Expression of Apoptosis-related MicroRNAs and Genes in Human Double Valve Replacement
Central South University1 site in 1 country8 target enrollmentStarted: March 2013Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- Change from Baseline in Cardiac MicroRNA Expression
Study Overview
Brief Summary
- Cardiopulmonary bypass and cardioplegic arrest could regulate expression of microRNAs in patients undergoing double valve replacement (aortic and mitral).
- The modulation of myocardial microRNAs by cardiopulmonary bypass and cardioplegic arrest may be rescued by ischemic postconditioning.
- Downstream effectors would also be affected.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 20 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Consecutive eight patients with rheumatic heart valve disease undergoing elective double valve replacement(aortic and mitral)are considered for participation in this study.
Exclusion Criteria
- •insulin-dependent diabetes mellitus
- •pulmonary, renal, or hepatic failure
- •infective valve disease
- •valve disease with coronary artery disease
- •hypertension
- •emergency and reoperations
- •received aspirin,corticosteroids, or statin preoperatively
- •received preoperative inotropic support
Outcomes
Primary Outcomes
Change from Baseline in Cardiac MicroRNA Expression
Time Frame: before cardiopulmonary bypass and at 5 min after aortic de-clamping
Samples were harvested from all the patients, respectively, before cardiopulmonary bypass and at 5 min after aortic de-clamping. Real-time quantitative stem-loop reverse transcription polymerase chain reaction assay was performed to detect the expression of microRNAs.
Secondary Outcomes
- Change from Baseline in Downstream Gene Expression(before cardiopulmonary bypass and at 5 min after aortic de-clamping)
Investigators
Luo Wanjun
Prof.
Central South University
Study Sites (1)
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