Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

Phase 3

Active, not recruiting

• Conditions: Metastatic Colorectal Cancer; Advanced Colorectal Cancer
• Interventions: Drug: MRTX849; Drug: mFOLFOX6 Regimen; Drug: FOLFIRI Regimen; Biological: Cetuximab

• Registration Number: NCT04793958
• Lead Sponsor: Mirati Therapeutics Inc.

Brief Summary

Study CA239-0006 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-03-02
• Study First Submitted QC: 2021-03-08
• Study First Posted: 2021-03-11
• Study Start: 2021-06-24
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-10
• Last Update Posted: 2025-02-11
• Primary Completion: 2026-01-30
• Study Completion: 2026-01-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 461

Inclusion Criteria

• Histologically confirmed diagnosis of colorectal carcinoma with KRAS G12C mutation in tumor tissue.
• Prior receipt of 1st line treatment in advanced CRC with a fluoropyrimidine-based chemotherapy regimen containing either oxaliplatin or irinotecan, and radiographically documented progression of disease on or after treatment.

Exclusion Criteria

• Prior treatment with a therapy targeting KRAS G12C mutation (e.g., AMG 510).
• Prior treatment with an anti-EGFR antibody (e.g., cetuximab or panitumumab).
• Active brain metastasis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
MRTX849 + Cetuximab	MRTX849	-
mFOLFOX6 or FOLFIRI	FOLFIRI Regimen	-
mFOLFOX6 or FOLFIRI	mFOLFOX6 Regimen	-
MRTX849 + Cetuximab	Cetuximab	-

Primary Outcome Measures

Name	Time	Method
Overall Survival (OS)	30 months	Defined as time from date of randomization to date of death due to any cause.
Progression-free Survival (PFS)	30 months	Defined as time from randomization until disease progression or death from any cause, whichever occurs first.

Secondary Outcome Measures

Name	Time	Method
Objective Response Rate (ORR)	30 months	Defined as the percent of patients documented to have a confirmed CR or PR.
Patient Reported Outcomes (PROs)	30 months	To be assessed by European Quality of Life Questionnaire for Cancer Patients (QLQ-C30).
Duration of Response (DOR)	30 months	Defined as the time from date of the first documentation of objective tumor response (CR or PR) to the first documentation of either Progression of Disease (PD) or death due to any cause, whichever occurs first.
Adverse Events	30 months	Defined as number of patients with treatment emergent AEs.
Quality of Life Assessment	30 months	To be assessed by European Quality of Life Five Dimensions Questionnaire (EQ-5D-5L).

Trial Locations

Locations (419)

Local Institution - 010-116; 🇰🇷 Anyang-si, Korea, Republic of

Local Institution - 010-111; 🇰🇷 Busan, Korea, Republic of

Local Institution - 010-100; 🇰🇷 Hwasun-gun, Korea, Republic of

Local Institution - 010-114; 🇰🇷 Seoul, Korea, Republic of

Local Institution - 010-109; 🇰🇷 Seoul, Korea, Republic of

Local Institution - 010-328; 🇵🇱 Gdansk, Poland

Local Institution - 010-327; 🇵🇱 Otwock, Poland

Local Institution - 010-322; 🇵🇱 Warszawa, Poland

Local Institution - 010-337; 🇵🇹 Lisbon, Portugal

Local Institution - 010-511; 🇷🇴 Ovidiu, Romania

Local Institution - 010-092; 🇸🇬 Singapore, Singapore

Local Institution - 010-613; 🇪🇸 A Coruna, Spain

Local Institution - 010-600; 🇪🇸 Barcelona, Spain

Local Institution - 010-621; 🇪🇸 Cordoba, Spain

Local Institution - 010-624; 🇪🇸 Madrid, Spain

Local Institution - 010-121; 🇨🇳 Kaohsiung, Taiwan

Local Institution - 010-125; 🇨🇳 Taoyuan, Taiwan

Local Institution - 010-130; 🇹🇭 Hat Yai, Thailand

Local Institution - 010-414; 🇬🇧 Leeds, United Kingdom

Local Institution - 010-404; 🇬🇧 Middlesex, United Kingdom

Local Institution - 010-535 - D; 🇺🇸 Babylon, New York, United States

Local Institution - 010-535 - E; 🇺🇸 Bronx, New York, United States

Local Institution - 010-918; 🇺🇸 New York, New York, United States

Local Institution - 010-535 - F; 🇺🇸 Riverhead, New York, United States

Local Institution - 010-577-B; 🇺🇸 Houston, Texas, United States

Local Institution - 010-577; 🇺🇸 Houston, Texas, United States

Local Institution - 010-976-A; 🇺🇸 Murray, Utah, United States

Local Institution - 010-923-H; 🇺🇸 Largo, Florida, United States

Local Institution - 010-923-K; 🇺🇸 Largo, Florida, United States

Local Institution - 010-923-L; 🇺🇸 Largo, Florida, United States

Local Institution - 010-990; 🇺🇸 Miami, Florida, United States

Local Institution - 010-538; 🇺🇸 Ocala, Florida, United States

Local Institution - 010-984; 🇺🇸 Saint Petersburg, Florida, United States

Local Institution - 010-963; 🇺🇸 Naperville, Illinois, United States

Local Institution - 010-569; 🇺🇸 Indianapolis, Indiana, United States

Local Institution - 010-531A; 🇺🇸 Brownstown, Michigan, United States

Local Institution - 010-531C; 🇺🇸 Dearborn, Michigan, United States

Local Institution - 010-838D; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-838G; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-838L; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-860 - A; 🇺🇸 Henderson, Nevada, United States

Local Institution - 010-975; 🇺🇸 East Brunswick, New Jersey, United States

Local Institution - 010-923-A; 🇺🇸 Largo, Florida, United States

Local Institution - 010-923-F; 🇺🇸 Largo, Florida, United States

Local Institution - 010-923-I; 🇺🇸 Largo, Florida, United States

Local Institution - 010-923-O; 🇺🇸 Largo, Florida, United States

Local Institution - 010-922-G; 🇺🇸 Naples, Florida, United States

Local Institution - 010-896; 🇺🇸 Orlando, Florida, United States

Local Institution - 010-924; 🇺🇸 Tallahassee, Florida, United States

Local Institution - 010-531B; 🇺🇸 Novi, Michigan, United States

Local Institution - 010-838; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-838C; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-564; 🇺🇸 Lincoln, Nebraska, United States

Local Institution - 010-860-B; 🇺🇸 Henderson, Nevada, United States

Local Institution - 010-860-E; 🇺🇸 Las Vegas, Nevada, United States

Local Institution - 010-976-H; 🇺🇸 Ogden, Utah, United States

Local Institution - 010-919; 🇺🇸 Fairfax, Virginia, United States

Local Institution - 010-976-C; 🇺🇸 Bountiful, Utah, United States

Local Institution - 010-976-D; 🇺🇸 Layton, Utah, United States

Local Institution - 010-976-G; 🇺🇸 Provo, Utah, United States

Local Institution - 010-976-B; 🇺🇸 Salt Lake City, Utah, United States

Local Institution - 010-432; 🇦🇷 Caba, Argentina

Local Institution - 010-002; 🇦🇺 Waratah, Australia

Local Institution - 010-150; 🇧🇪 Yvoir, Belgium

Local Institution - 010-449; 🇧🇷 Liberdade, Brazil

Local Institution - 010-031; 🇨🇳 Guangzhou, Guangdong, China

Local Institution - 010-036; 🇨🇳 Jinan, Shandong, China

Local Institution - 010-162; 🇨🇿 Olomouc, Czechia

Local Institution - 010-180; 🇫🇮 Helsinki, Finland

Local Institution - 010-668; 🇫🇷 Avignon, France

Local Institution - 010-194; 🇫🇷 Brest, France

Local Institution - 010-682; 🇫🇷 Marseille Cedex 5, France

Local Institution - 010-656; 🇩🇪 Hamburg, Germany

Local Institution - 010-658; 🇩🇪 Herne, Germany

Local Institution - 010-226; 🇩🇪 Munchen, Germany

Local Institution - 010-652; 🇩🇪 Reutlingen, Germany

Local Institution - 010-231; 🇬🇷 Thessaloniki, Greece

Local Institution - 010-253; 🇮🇪 Dublin, Ireland

Local Institution - 010-287; 🇮🇹 Lido di Camaiore, Italy

Local Institution - 010-270; 🇮🇹 Meldola, Italy

Local Institution - 010-291; 🇮🇹 Reggio Emilia, Italy

Local Institution - 010-289; 🇮🇹 Torino, Italy

Local Institution - 010-119; 🇰🇷 Busan, Korea, Republic of

Local Institution - 010-117; 🇰🇷 Goyang-si, Korea, Republic of

Local Institution - 010-108; 🇰🇷 Seoul, Korea, Republic of

Local Institution - 010-524; 🇰🇷 Yangsan-si, Korea, Republic of

Local Institution - 010-074; 🇲🇾 Kuala Lumpur, Malaysia

Local Institution - 010-472; 🇲🇽 Guadalajara, Jalisco, Mexico

Local Institution - 010-477; 🇲🇽 Guadalajara, Jalisco, Mexico

Local Institution - 010-576; 🇺🇸 Everett, Washington, United States

Local Institution - 010-533 C; 🇺🇸 Puyallup, Washington, United States

Local Institution - 010-575; 🇺🇸 Morgantown, West Virginia, United States

Local Institution - 010-947; 🇺🇸 Milwaukee, Wisconsin, United States

Local Institution - 010-431; 🇦🇷 Buenos Aires, Argentina

Local Institution - 010-430; 🇦🇷 La Rioja, Argentina

Local Institution - 010-012; 🇦🇺 Melbourne, Australia

Local Institution - 010-145; 🇦🇹 Innsbruck, Austria

Local Institution - 010-157; 🇧🇪 Edegem, Belgium

Local Institution - 010-156; 🇧🇪 Gent, Belgium

Local Institution - 010-442; 🇧🇷 Curitiba, Brazil

Local Institution - 010-481; 🇨🇦 Ottawa, Ontario, Canada

Local Institution - 010-483; 🇨🇦 Toronto, Ontario, Canada

Local Institution - 010-482; 🇨🇦 Toronto, Ontario, Canada

Local Institution - 010-029; 🇨🇳 Fuzhou, Fujian, China

Local Institution - 010-704; 🇨🇳 Nanjing, Jiangsu, China

Local Institution - 010-027; 🇨🇳 Tianjin, Tianjin, China

Local Institution - 010-034; 🇨🇳 Hangzhou, Zhejiang, China

Local Institution - 010-033; 🇨🇳 Hongkou Qu, China

Local Institution - 010-462; 🇨🇴 Bogota, Colombia

Local Institution - 010-171; 🇩🇰 Copenhagen, Denmark

Local Institution - 010-170; 🇩🇰 Vejle, Denmark

Local Institution - 010-662; 🇫🇷 Lille, France

Local Institution - 010-205; 🇫🇷 Lyon, France

Local Institution - 010-203; 🇫🇷 Paris Cedex 12, France

Local Institution - 010-204; 🇫🇷 Paris, France

Local Institution - 010-661; 🇫🇷 Paris, France

Local Institution - 010-667; 🇫🇷 Suresnes, France

Local Institution - 010-229; 🇩🇪 Frankfurt am Main, Germany

Local Institution - 010-230; 🇬🇷 Thessaloniki, Greece

Local Institution - 010-290; 🇮🇹 Biella, Italy

Local Institution - 010-286; 🇮🇹 Candiolo, Italy

Local Institution - 010-473; 🇲🇽 Mexico City, Distrito Federal, Mexico

Local Institution - 010-520; 🇰🇷 Seongnam-si, Korea, Republic of

Local Institution - 010-118; 🇰🇷 Seoul, Korea, Republic of

Local Institution - 010-104; 🇰🇷 Seoul, Korea, Republic of

Local Institution - 010-070; 🇲🇾 Johor Bahru, Johor, Malaysia

Local Institution - 010-238; 🇬🇷 Heraklion, Greece

Local Institution - 010-235; 🇬🇷 Larissa, Greece

Local Institution - 010-048; 🇭🇰 Central, Hong Kong

Local Institution - 010-046; 🇭🇰 Hong Kong, Hong Kong

Local Institution - 010-251; 🇮🇪 Dublin, Ireland

Local Institution - 010-292; 🇮🇹 Avellino, Italy

Local Institution - 010-299; 🇮🇹 Cagliari, Italy

Local Institution - 010-293; 🇮🇹 Milano, Italy

Local Institution - 010-278; 🇮🇹 Milan, Italy

Local Institution - 010-295; 🇮🇹 Roma, Italy

Local Institution - 010-271; 🇮🇹 Napoli, Italy

Local Institution - 010-433; 🇦🇷 Viedma, Argentina

Local Institution - 010-144; 🇦🇹 Wien, Austria

Local Institution - 010-154; 🇧🇪 Brussel, Belgium

Local Institution - 010-182; 🇫🇮 Tampere, Finland

Local Institution - 010-181; 🇫🇮 Turku, Finland

Local Institution - 010-207; 🇫🇷 Paris, France

Local Institution - 010-657; 🇩🇪 Berlin, Germany

Local Institution - 010-655; 🇩🇪 Bochum, Germany

Local Institution - 010-227; 🇩🇪 Dresden, Germany

Local Institution - 010-228; 🇩🇪 Monchengladbach, Germany

Local Institution - 010-650; 🇩🇪 Munchen, Germany

Local Institution - 010-855-E; 🇺🇸 Alabaster, Alabama, United States

Local Institution - 010-855-D; 🇺🇸 Birmingham, Alabama, United States

Local Institution - 010-855-A; 🇺🇸 Birmingham, Alabama, United States

Local Institution - 010-855; 🇺🇸 Birmingham, Alabama, United States

Local Institution - 010-551; 🇺🇸 Los Angeles, California, United States

Local Institution - 010-563; 🇺🇸 Redlands, California, United States

Local Institution - 010-979; 🇺🇸 San Diego, California, United States

Local Institution - 010-574; 🇺🇸 Torrance, California, United States

Local Institution - 010-872-E; 🇺🇸 Centennial, Colorado, United States

Local Institution - 010-855-F; 🇺🇸 Birmingham, Alabama, United States

Local Institution - 010-566; 🇺🇸 Goodyear, Arizona, United States

Local Institution - 010-979A; 🇺🇸 La Mesa, California, United States

Local Institution - 010-872-G; 🇺🇸 Longmont, Colorado, United States

Local Institution - 010-922-E; 🇺🇸 Cape Coral, Florida, United States

Local Institution - 010-923-G; 🇺🇸 Largo, Florida, United States

Local Institution - 010-988; 🇺🇸 Orlando, Florida, United States

Local Institution - 010-922-H; 🇺🇸 Port Charlotte, Florida, United States

Local Institution - 010-984-A; 🇺🇸 Trinity, Florida, United States

Local Institution - 010-926; 🇺🇸 West Palm Beach, Florida, United States

Local Institution - 010-537; 🇺🇸 Weston, Florida, United States

Local Institution - 010-855-C; 🇺🇸 Birmingham, Alabama, United States

Local Institution - 010-989; 🇺🇸 Phoenix, Arizona, United States

Local Institution - 010-980; 🇺🇸 Fresno, California, United States

Local Institution - 010-855-B; 🇺🇸 Bessemer, Alabama, United States

Local Institution - 010-996; 🇺🇸 Gilbert, Arizona, United States

Local Institution - 010-978; 🇺🇸 Springdale, Arkansas, United States

Local Institution - 010-573; 🇺🇸 Bakersfield, California, United States

Local Institution - 010-979C; 🇺🇸 Chula Vista, California, United States

Local Institution - 010-851; 🇺🇸 Fullerton, California, United States

Local Institution - 010-847; 🇺🇸 Newport Beach, California, United States

Local Institution - 010-979D; 🇺🇸 San Diego, California, United States

Local Institution - 010-872-B; 🇺🇸 Denver, Colorado, United States

Local Institution - 010-872-F; 🇺🇸 Littleton, Colorado, United States

Local Institution - 010-872-D; 🇺🇸 Thornton, Colorado, United States

Local Institution - 010-922; 🇺🇸 Fort Myers, Florida, United States

Local Institution - 010-923-C; 🇺🇸 Largo, Florida, United States

Local Institution - 010-923-D; 🇺🇸 Largo, Florida, United States

Local Institution - 010-923-E; 🇺🇸 Largo, Florida, United States

Local Institution - 010-923-J; 🇺🇸 Largo, Florida, United States

Local Institution - 010-923-M; 🇺🇸 Largo, Florida, United States

Local Institution - 010-986; 🇺🇸 Newnan, Georgia, United States

Local Institution - 010-991; 🇺🇸 Iowa City, Iowa, United States

Local Institution - 010-531; 🇺🇸 Detroit, Michigan, United States

Local Institution - 010-830; 🇺🇸 Rochester, Minnesota, United States

Local Institution - 010-838K; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-838M; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-860; 🇺🇸 Las Vegas, Nevada, United States

Local Institution - 010-957; 🇺🇸 New Brunswick, New Jersey, United States

Local Institution - 010-676; 🇩🇪 Ulm, Germany

Local Institution - 010-872; 🇺🇸 Denver, Colorado, United States

Local Institution - 010-501; 🇬🇷 Athens, Greece

Local Institution - 010-232; 🇬🇷 Cholargos, Greece

Local Institution - 010-956; 🇺🇸 Atlanta, Georgia, United States

Local Institution - 010-872-J; 🇺🇸 Lakewood, Colorado, United States

Local Institution - 010-090; 🇸🇬 Singapore, Singapore

Local Institution - 010-922-B; 🇺🇸 Fort Myers, Florida, United States

Local Institution - 010-105; 🇰🇷 Seoul, Korea, Republic of

Local Institution - 010-958A; 🇺🇸 Los Angeles, California, United States

Local Institution - 010-958; 🇺🇸 Los Angeles, California, United States

Local Institution - 010-979B; 🇺🇸 San Diego, California, United States

Local Institution - 010-982; 🇺🇸 San Francisco, California, United States

Local Institution - 010-571; 🇺🇸 Sylmar, California, United States

Local Institution - 010-872-H; 🇺🇸 Aurora, Colorado, United States

Local Institution - 010-872-A; 🇺🇸 Boulder, Colorado, United States

Local Institution - 010-872-C; 🇺🇸 Colorado Springs, Colorado, United States

Local Institution - 010-561; 🇺🇸 Santa Monica, California, United States

Local Institution - 010-570; 🇺🇸 Whittier, California, United States

Local Institution - 010-810; 🇺🇸 Aurora, Colorado, United States

Local Institution - 010-872-I; 🇺🇸 Pueblo, Colorado, United States

Local Institution - 010-949; 🇺🇸 Norwich, Connecticut, United States

Local Institution - 010-922-D; 🇺🇸 Bradenton, Florida, United States

Local Institution - 010-922-C; 🇺🇸 Fort Myers, Florida, United States

Local Institution - 010-984-B; 🇺🇸 Holiday, Florida, United States

Local Institution - 010-918 - F; 🇺🇸 Harrison, New York, United States

Local Institution - 010-535 - G; 🇺🇸 New York, New York, United States

Local Institution - 010-998; 🇺🇸 New York, New York, United States

Local Institution - 010-535 - B; 🇺🇸 Port Jefferson Station, New York, United States

Local Institution - 010-922-A; 🇺🇸 Bonita Springs, Florida, United States

Local Institution - 010-838E; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-838H; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-838I; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-838J; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-860-D; 🇺🇸 Las Vegas, Nevada, United States

Local Institution - 010-918 - B; 🇺🇸 Basking Ridge, New Jersey, United States

Local Institution - 010-918 - A; 🇺🇸 Commack, New York, United States

Local Institution - 010-918 - E; 🇺🇸 Uniondale, New York, United States

Local Institution - 010-549; 🇺🇸 Oklahoma City, Oklahoma, United States

Local Institution - 010-584; 🇺🇸 Tulsa, Oklahoma, United States

Local Institution - 010-572; 🇺🇸 Dallas, Texas, United States

Local Institution - 010-577-A; 🇺🇸 Houston, Texas, United States

Local Institution - 010-976; 🇺🇸 Salt Lake City, Utah, United States

Local Institution - 010-976-E; 🇺🇸 West Jordan, Utah, United States

Local Institution - 010-539; 🇺🇸 Richmond, Virginia, United States

Local Institution - 010-434; 🇦🇷 Buenos Aires, Argentina

Local Institution - 010-829; 🇺🇸 Jacksonville, Florida, United States

Local Institution - 010-923-B; 🇺🇸 Largo, Florida, United States

Local Institution - 010-923-N; 🇺🇸 Largo, Florida, United States

Local Institution - 010-923-P; 🇺🇸 Largo, Florida, United States

Local Institution - 010-922-F; 🇺🇸 Naples, Florida, United States

Local Institution - 010-923; 🇺🇸 Saint Petersburg, Florida, United States

Local Institution - 010-994; 🇺🇸 Zion, Illinois, United States

Local Institution - 010-997; 🇺🇸 Boston, Massachusetts, United States

Local Institution - 010-875; 🇺🇸 Minneapolis, Minnesota, United States

Local Institution - 010-838A; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-541; 🇺🇸 Springfield, Missouri, United States

Local Institution - 010-993; 🇺🇸 Belleville, New Jersey, United States

Local Institution - 010-992; 🇺🇸 Florham Park, New Jersey, United States

Local Institution - 010-918 - D; 🇺🇸 Middletown, New Jersey, United States

Local Institution - 010-918 - C; 🇺🇸 Montvale, New Jersey, United States

Local Institution - 010-535 - C; 🇺🇸 Patchogue, New York, United States

Local Institution - 010-535; 🇺🇸 Shirley, New York, United States

Local Institution - 010-585-A; 🇺🇸 Jacksonville, North Carolina, United States

Local Institution - 010-532; 🇺🇸 Oklahoma City, Oklahoma, United States

Local Institution - 010-596; 🇺🇸 Pittsburgh, Pennsylvania, United States

Local Institution - 010-921; 🇺🇸 Chattanooga, Tennessee, United States

Local Institution - 010-964; 🇺🇸 Temple, Texas, United States

Local Institution - 010-878; 🇺🇸 Tyler, Texas, United States

Local Institution - 010-976-F; 🇺🇸 American Fork, Utah, United States

Local Institution - 010-569-A; 🇺🇸 Indianapolis, Indiana, United States

Local Institution - 010-920; 🇺🇸 Baton Rouge, Louisiana, United States

Local Institution - 010-534; 🇺🇸 Baltimore, Maryland, United States

Local Institution - 010-838B; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-838F; 🇺🇸 Saint Louis Park, Minnesota, United States

Local Institution - 010-590; 🇺🇸 Omaha, Nebraska, United States

Local Institution - 010-860-F; 🇺🇸 Henderson, Nevada, United States

Local Institution - 010-860-C; 🇺🇸 Las Vegas, Nevada, United States

Local Institution - 010-813; 🇺🇸 New York, New York, United States

Local Institution - 010-585-B; 🇺🇸 Clinton, North Carolina, United States

Local Institution - 010-585; 🇺🇸 Goldsboro, North Carolina, United States

Local Institution - 010-801; 🇺🇸 Nashville, Tennessee, United States

Local Institution - 010-879; 🇺🇸 Dallas, Texas, United States

Local Institution - 010-977; 🇺🇸 Houston, Texas, United States

Local Institution - 010-878-B; 🇺🇸 Longview, Texas, United States

Local Institution - 010-597; 🇺🇸 Fredericksburg, Virginia, United States

Local Institution - 010-536; 🇺🇸 Richmond, Virginia, United States

Local Institution - 010-885; 🇺🇸 Vancouver, Washington, United States

Local Institution - 010-005; 🇦🇺 Bedford Park, Australia

Local Institution - 010-004; 🇦🇺 Clayton, Australia

Local Institution - 010-006; 🇦🇺 Garran, Australia

Local Institution - 010-015; 🇦🇺 Heidelberg, Australia

Local Institution - 010-444; 🇧🇷 Santo Andre, Brazil

Local Institution - 010-487; 🇨🇦 Montreal, Quebec, Canada

Local Institution - 010-713; 🇨🇳 Shenzhen, Guangdong, China

Local Institution - 010-703; 🇨🇳 Wuhan, Hubei, China

Local Institution - 010-035; 🇨🇳 Changsha, Hunan, China

Local Institution - 010-030; 🇨🇳 Changchun, Jilin, China

Local Institution - 010-718; 🇨🇳 Changchun, Jilin, China

Local Institution - 010-025; 🇨🇳 Shanghai Shi, Shanghai, China

Local Institution - 010-038; 🇨🇳 Shanghai, Shanghai, China

Local Institution - 010-020; 🇨🇳 Shanghai, Shanghai, China

Local Institution - 010-463; 🇨🇴 Medellin, Colombia

Local Institution - 010-209-A; 🇫🇷 Chambray-les-Tours, Centre-Val De Loire, France

Local Institution - 010-669; 🇫🇷 Bordeaux, France

Local Institution - 010-192; 🇫🇷 Dijon cedex, France

Local Institution - 010-202; 🇫🇷 Villejuif, France

Local Institution - 010-675; 🇩🇪 Amberg, Germany

Local Institution - 010-535 - A; 🇺🇸 Port Jefferson, New York, United States

Local Institution - 010-893; 🇺🇸 Cincinnati, Ohio, United States

Local Institution - 010-981; 🇺🇸 Greenville, South Carolina, United States

Local Institution - 010-848; 🇺🇸 Houston, Texas, United States

Local Institution - 010-999; 🇺🇸 Irving, Texas, United States

Local Institution - 010-862; 🇺🇸 San Antonio, Texas, United States

Local Institution - 010-533 A; 🇺🇸 Auburn, Washington, United States

Local Institution - 010-533 B; 🇺🇸 Gig Harbor, Washington, United States

Local Institution - 010-824; 🇺🇸 Seattle, Washington, United States

Local Institution - 010-533; 🇺🇸 Tacoma, Washington, United States

Local Institution - 010-448; 🇦🇷 Porto Alegre, Argentina

Local Institution - 010-143; 🇦🇹 Wiener Neustadt, Austria

Local Institution - 010-446; 🇧🇷 Ijui, Rio Grande Do Sul, Brazil

Local Institution - 010-440; 🇧🇷 Sao Jose do Rio Preto, Brazil

Local Institution - 010-441; 🇧🇷 Sao Paolo, Brazil

Local Institution - 010-445; 🇧🇷 Sao Paulo, Brazil

Local Institution - 010-026; 🇨🇳 Hefei Shi, Anhui, China

Local Institution - 010-022; 🇨🇳 Hefei, Anhui, China

Local Institution - 010-711; 🇨🇳 Hefei, Anhui, China

Local Institution - 010-717; 🇨🇳 Beijing, Beijing, China

Local Institution - 010-021; 🇨🇳 Zhengzhou City, Henan, China

Local Institution - 010-706; 🇨🇳 Nanchang, Jiangxi, China

Local Institution - 010-710; 🇨🇳 Chengdu, Sichuan, China

Local Institution - 010-716; 🇨🇳 Neijiang, Sichuan, China

Local Institution - 010-032; 🇨🇳 Hangzhou, China

Local Institution - 010-465; 🇨🇴 Floridablanca, Colombia

Local Institution - 010-160; 🇨🇿 Brno, Czechia

Local Institution - 010-161; 🇨🇿 Praha 5, Czechia

Local Institution - 010-443; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

Local Institution - 010-450; 🇧🇷 Blumenau, Santa Catarina, Brazil

Local Institution - 010-447; 🇧🇷 Sao Paulo, Brazil

Local Institution - 010-712; 🇨🇳 Bengbu, Anhui, China

Local Institution - 010-715; 🇨🇳 Nanning, Guangxi, China

Local Institution - 010-701; 🇨🇳 Wuhan, Hubei, China

Local Institution - 010-714; 🇨🇳 Jiangyin, Jiangsu, China

Local Institution - 010-709; 🇨🇳 Shenyang, Liaoning, China

Local Institution - 010-705; 🇨🇳 Shenyang, Liaoning, China

Local Institution - 010-024; 🇨🇳 Shanghaishi, Shanghai, China

Local Institution - 010-708; 🇨🇳 Shanghai, Shanghai, China

Local Institution - 010-707; 🇨🇳 Hangzhou, Zhejiang, China

Local Institution - 010-460; 🇨🇴 Barranquilla, Colombia

Local Institution - 010-165; 🇨🇿 Brno, Czechia

Local Institution - 010-172; 🇩🇰 Odense, Denmark

Local Institution - 010-208; 🇫🇷 Besancon, France

Local Institution - 010-660; 🇫🇷 Pessac, France

Local Institution - 010-680; 🇫🇷 Toulouse cedex 9, France

Local Institution - 010-209; 🇫🇷 Tours Cedex 9, France

Local Institution - 010-250; 🇮🇪 Dublin, Ireland

Local Institution - 010-252; 🇮🇪 Dublin, Ireland

Local Institution - 010-254; 🇮🇪 Dublin, Ireland

Local Institution - 010-297; 🇮🇹 Padova, Italy

Local Institution - 010-294; 🇮🇹 Pisa, Italy

Local Institution - 010-525; 🇰🇷 Daejeon, Korea, Republic of

Local Institution - 010-071; 🇲🇾 Petaling Jaya, Selangor, Malaysia

Local Institution - 010-471; 🇲🇽 Colonia Centro Orizaba, Veracruz, Mexico

Local Institution - 010-306; 🇳🇱 Amsterdam, Netherlands

Local Institution - 010-787; 🇵🇱 Warszawa, Poland

Local Institution - 010-332; 🇵🇹 Braga, Portugal

Local Institution - 010-900; 🇵🇷 San Juan, Puerto Rico

Local Institution - 010-093; 🇸🇬 Singapore, Singapore

Local Institution - 010-095; 🇸🇬 Singapore, Singapore

Local Institution - 010-475; 🇲🇽 San Juan del Rio, Queretaro, Mexico

Local Institution - 010-630; 🇳🇱 Nijmegen, Netherlands

Local Institution - 010-640; 🇵🇹 Lisbon, Portugal

Local Institution - 010-349; 🇷🇴 Brasov, Romania

Local Institution - 010-344; 🇷🇴 Cluj-Napoca, Romania

Local Institution - 010-340; 🇷🇴 Cluj-Napoca, Romania

Local Institution - 010-343; 🇷🇴 Craiova, Romania

Local Institution - 010-091; 🇸🇬 Singapore, Singapore

Local Institution - 010-601; 🇪🇸 Madrid, Spain

Local Institution - 010-622; 🇪🇸 Sabadell, Spain

Local Institution - 010-618; 🇪🇸 Valencia, Spain

Local Institution - 010-132; 🇹🇭 Bang Phlat, Thailand

Local Institution - 010-133; 🇹🇭 Khlong Toey, Thailand

Local Institution - 010-412; 🇬🇧 Aberdeen, United Kingdom

Local Institution - 010-413; 🇬🇧 Cambridge, United Kingdom

Local Institution - 010-411; 🇬🇧 Dorset, United Kingdom

Local Institution - 010-400; 🇬🇧 Glasgow, United Kingdom

Local Institution - 010-403; 🇬🇧 Kent, United Kingdom

Local Institution - 010-405; 🇬🇧 London, United Kingdom

Local Institution - 010-632; 🇳🇱 Amsterdam, Netherlands

Local Institution - 010-115; 🇰🇷 Suwon-Si, Korea, Republic of

Local Institution - 010-474; 🇲🇽 Tuxtla Gutierrez, Chiapas, Mexico

Local Institution - 010-476; 🇲🇽 Cuernavaca, Morelos, Mexico

Local Institution - 010-331; 🇵🇹 Porto, Portugal

Local Institution - 010-339; 🇵🇹 Porto, Portugal

Local Institution - 010-902; 🇵🇷 San Juan, Puerto Rico

Local Institution - 010-347; 🇷🇴 Baia Mare, Romania

Local Institution - 010-510; 🇷🇴 Timisoara, Romania

Local Institution - 010-612; 🇪🇸 Barcelona, Spain

Local Institution - 010-619; 🇪🇸 Madrid, Spain

Local Institution - 010-617; 🇪🇸 Madrid, Spain

Local Institution - 010-623; 🇪🇸 Pamplona, Spain

Local Institution - 010-122; 🇨🇳 Tainan, Taiwan

Local Institution - 010-424; 🇺🇦 Sumy, Ukraine

Local Institution - 010-402; 🇬🇧 London, United Kingdom

Local Institution - 010-406; 🇬🇧 London, United Kingdom

Local Institution - 010-407; 🇬🇧 Manchester, United Kingdom

Local Institution - 010-077; 🇲🇾 Kota Kinabalu, Sabah, Malaysia

Local Institution - 010-073; 🇲🇾 Kuala Lumpur, Malaysia

Local Institution - 010-072; 🇲🇾 Putrajaya, Malaysia

Local Institution - 010-307; 🇳🇱 Utrecht, Netherlands

Local Institution - 010-903; 🇵🇷 San Juan, Puerto Rico

Local Institution - 010-512; 🇷🇴 Bucharest, Romania

Local Institution - 010-610; 🇪🇸 Badalona, Spain

Local Institution - 010-604; 🇪🇸 Santander, Spain

Local Institution - 010-123; 🇨🇳 Tainan City, Taiwan

Local Institution - 010-134; 🇹🇭 Bangkok, Thailand

Local Institution - 010-410; 🇬🇧 Birmingham, United Kingdom

Local Institution - 010-620; 🇪🇸 LHospitalet de Llobregat, Spain

Local Institution - 010-625; 🇪🇸 Valencia, Spain

Local Institution - 010-129; 🇨🇳 Changhua City, Taiwan

Local Institution - 010-124; 🇨🇳 Taichung, Taiwan

Local Institution - 010-120; 🇨🇳 Taipei City, Taiwan

Local Institution - 010-131; 🇹🇭 Chiang Mai, Thailand