Optimising the cardiovascular system following liver transplantation surgery
- Conditions
- iver transplantation for liver cirrhosisDigestive SystemLiver transplantation for liver cirrhosis
- Registration Number
- ISRCTN10329248
- Lead Sponsor
- niversity College London
- Brief Summary
2018 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/29514697 protocol 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/31874736/ results (added 16/07/2020) 2018 Abstract results in https://doi.org/10.1177/2050640618812015 (added 19/05/2023)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
1. Aged between 18 and 80 years
2. Liver cirrhosis
3. Selected to undergo liver transplantation
4. Competent to give consent
1. Non-cirrhotic liver disease
2. Pregnancy
3. Age less than 18 years or over 80 years
4. Body weight less than 40 kg
5. Re-transplantation for primary graft non-function
6. Fulminant hepatic failure
7. Emergency surgery
8. Known learning disabilities or previously lacking capacity to consent for themselves
9. Prisoners
10. Patients already enrolled in an interventional study
11. Refusal or inability to consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Feasibility is determined at the end of the study period as the:<br>1. Ability to recruit patients at the site: A recruitment rate of greater than 40% of patients fulfilling the criteria for this study will be deemed as successful<br>2. Rate of withdrawal from GDFT protocol: A withdrawal rate of less than 10% will be deemed as successful<br>3. Reasons for withdrawal from GDFT protocol: Qualitatively assessed<br>4. Ability to adhere to the GDFT protocol for the 12 hour intervention period: Less than 10% of patients with a deviation from the protocol will indicate success
- Secondary Outcome Measures
Name Time Method