Characterization of metabolic changes in the glioma tumor tissue induced by transient fasting: a pilot study

Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main0 个研究点目标入组 30 人开始时间: 2020年5月12日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•age >= 18 years
•suspicion of glioma World Health Organization (WHO) grade II, III or IV as assessed by cerebral imaging (MRI)
•MRI-suspected relapse of previously diagnosed glioma
•interdisciplinary recommendation for resection or biopsy
•karnofsky performance status >= 60, Eastern Cooperative Oncology Group Performance Status (ECOG) <= 2
•creatinine <= 2,0 mg/dl, urea <= 100 mg/dl
•ALAT, ASAT <= 7x upper normal limit
•INR = 1,5, thrombocytes > 100000/µl, leukocytes > 3000/µl

•bowel obstruction, subileus
•insulin-dependent diabetes
•dexamethasone >4mg/day
•decompensated heart failure (NYHA > 2)
•myocardial infarction within the last 6 months, symptomatic atrial fibrillation
•severe acute infection or clinically relevant immunosuppression (HIV infection, granulocytopenia <1000/ µl, lymphocytopenia <500/ µl
•malnutrition, cachexia (BMI <18)
•other medical conditions that might increase the risk of the dietary intervention
•uncontrolled thyroid function
•pancreatic insufficiency
•dementia or other clinically relevant alterations of the mental status which could impair the ability of the patient to apply to the diet or understand the informed consent of the study
•major contraindications to MRI scanning (e.g. presence of implanted MRI-incompatible cardiac devices)

发起方

Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main