Osteoprotegerin Before and After Periodontal Surgery
Not Applicable
Completed
- Conditions
- Chronic Periodontitis
- Interventions
- Procedure: Open flap debridement
- Registration Number
- NCT02160613
- Lead Sponsor
- Cairo University
- Brief Summary
The study hypothesis:
Is Osteoprotegerin a diagnostic and/or prognostic marker of periodontal disease?
- Detailed Description
assessment of osteoprotegerin in patients with chronic periodontitis before and after periodontal surgery in gingival crevicular fluid, saliva and gingival tissues.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- severe chronic periodontitis, having pocket depth of ≥ 5 mm and clinical attachment level ≥ 5 mm
Exclusion Criteria
- pregnant women
- subjects had <22 permanent teeth
- having any given systemic disease
- taking any type of medication and/or antibiotic therapy during the 3 months before the study
- received periodontal treatment within the past 12 months
- current or former smokers.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Open flap for periodontitis patients Open flap debridement Open flap debridement
- Primary Outcome Measures
Name Time Method Change from baseline in Osteoprotegerin levels at 3 and 6 months Baseline, 3 months and 6 months
- Secondary Outcome Measures
Name Time Method Changes from baseline in probing pocket depth at 3 and 6 months baseline, 3 months and 6 months changes from baseline in Clinical attachment level at 3 and 6 months. Baseline, 3 months and 6 months Changes from baseline in gingival index at 3 and 6 months baseline, 3 months and 6 months Changes from baseline in plaque index at 3 and 6 months baseline, 3 months and 6 months
Trial Locations
- Locations (1)
Faculty of oral and dental medicine
🇪🇬Cairo, Egypt