A randomized clinical trial comparing preoperative continuation versus cessation of angiotensin converting enzyme inhibitors and angiotensin receptor blockers in patients undergoing elective, noncardiac surgery at a major tertiary hospital.

Not Applicable

Recruiting

• Conditions: cardiovascular mortality; cardiac arrest; noncardiac surgery; perioperative cardiovascular events; decompensated cardiac failure; myocardial infarction; myocardial injury after noncardiac surgery; acute kidney injury; cerebrovascular event; Anaesthesiology - Other anaesthesiology

• Registration Number: ACTRN12617001365358
• Lead Sponsor: Metro South Health - Princess Alexandra Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-09-27
• Last Update Posted: 9 May 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 666

Inclusion Criteria

•Adult (>18 years of age)
•Non-pregnant
•Patients at Princess Alexandra Hospital (Brisbane, Queensland)
•Attendance at preadmission clinic at least twenty-four hours prior to day of surgery
•Elective surgery
•Planned general anaesthetic
•Prescribed an ACEi or ARB on a stable dose for the previous twenty-eight days

Exclusion Criteria

•Systolic blood pressure greater than 180 mmHg noted on preadmission clinic visit
•Cardiac surgery
•Transplant surgery
•Cognitive impairment or other neurological disorders resulting in patients lacking capacity to provide informed consent and a legally authorized substitute decision maker (power of attorney or statutory health attorney or appointed guardian) does not exist or is unavailable to provide informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified