External Pressure Applied on the Caval Vein and Its Effects on Difference in Pulse Pressure (dPP) and Pleth Variability Index (PVI)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Change of dPP from start of intervention to 2 minutes after start of the intervention
研究概览
简要总结
Fluid therapy optimization in the perioperative period has been considered as major contributor to improve oxygen delivery. A recent, noninvasive approach to estimate fluid requirements in the anesthetized patient with arterial line is the assessment of difference in pulse pressure (dPP). Intraoperative fluid management by dPP is a goal-directed fluid management approach to avoid both hypervolemia and hypovolemia. However, several clinical factors may impede dPP measurements. Surgical manipulations in abdominal procedures may interfere with hemodynamic stability due to obstruction of the caval vein. Physiological considerations make us hypothesize that only intense pressure impedes caval blood flow and thus hemodynamics and dPP. Therefore, the investigators want to assess those changes after standardized application of three different pressure levels (2 N, 5 N, 10 N) on the caval vein.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for elective hepatic surgery procedures (hemihepatectomy) qualifying for arterial line
排除标准
- •pregnancy
- •cardiac insufficiency (NYHA 4, EF < 25 %)
- •coronary (CCS 4)
- •coagulopathy
- •symptoms of infection or sepsis
- •malignant hyperthermia
- •porphyria
- •oesophageal varicose veins
- •absence of sinus rhythm
结局指标
主要结局
Change of dPP from start of intervention to 2 minutes after start of the intervention
时间窗: Application of pressure for 2 minutes
次要结局
未报告次要终点
研究者
Lydia T. Strys
M.D.
Johannes Gutenberg University Mainz
