Pulmonary Fibrosis and Telomerase Mutation Study
- Conditions
- Pulmonary Fibrosis
- Registration Number
- NCT01501578
- Lead Sponsor
- Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires
- Brief Summary
This study is an observational and retrospective study of patients with pulmonary fibrosis associated or not with telomerase mutation.
The purpose of this study is to describe in detail the cases with telomerase mutation in terms of features on CT scan, respiratory function and evolution, in comparison to control subjects with idiopathic pulmonary fibrosis and no telomerase mutation identified or family history.
- Detailed Description
Two "control" subjects will be enrolled for one subject with telomerase mutation.
The data are all the results of investigations conducted for the diagnosis of idiopathic pulmonary fibrosis and during routine follow up of patients.
The CT scans will reviewed centrally to homogenize the description.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 81
- Diffuse interstitial lung disease on CT scan
- Telomerase mutation analysis
- Presence of connective tissue disease, or pneumoconiosis or drug induced lung disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Description of imaging pattern at baseline only Description of imaging pattern on representative CT scan at diagnosis.
- Secondary Outcome Measures
Name Time Method Pulmonary function tests from diagnosis to last follow-up, for an average of one year analyze the respiratory function
Pathology of the lung at baseline only description of pathological pattern
Trial Locations
- Locations (1)
Louis Pradel Hospital (Bâtiment A4)
🇫🇷Lyon, France