A Reduced 11-b-HSD Activity, a Novel Mechanism of Salt Sensitivity and Hypertension After Renal Allograft Donation?

Not Applicable

Completed

• Conditions: Renal Failure; Renal Transplantation; Living Donors
• Interventions: Dietary Supplement: Low and high salt diets

• Registration Number: NCT01009229
• Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Brief Summary

Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation according to official guidelines. An assessment of salt sensitivity, 11 beta HSD activity, 24 hour blood pressure, urine collection and physical exam will be performed prior nephrectomy and 14, 52, 156, 208 days post-nephrectomy.

Detailed Description

Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation. The assessment of salt sensitivity, 11 beta HSD activity, 24 hour blood pressure, urine collection and physical exam will be performed prior nephrectomy and 14, 52, 156, 208 days post-nephrectomy.

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2009-11-05
• Study First Submitted QC: 2009-11-05
• Study First Posted: 2009-11-06
• Primary Completion: 2010-07
• Study Completion: 2010-07
• Status Verified: 2011-05
• Last Update Submitted: 2011-05-24
• Last Update Posted: 2011-05-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• acceptance for living kidney donation

Exclusion Criteria

• withdrawal of consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
1	Low and high salt diets	-

Primary Outcome Measures

Name	Time	Method
Salt sensitivity, arterial hypertension	day 0, 14, 52, 156, 208, yearly

Trial Locations

Locations (1)

Department of nephrology and hypertension, Universitiy of Bern; 🇨🇭 Bern, Switzerland