Effect Of Dexmedetomidine Infusion On Intraoperative Hemodynamics And Anesthetic Requirements In Patients Undergoing Elective Spine Surgery: A Prospective Randomized Control Trial
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- BLOOD LOSS
研究概览
简要总结
Dexmedetomidine is a highly selectivealpha-2-agonist that has been widely used in anesthetic practice as an adjuvantbecause of its desirable properties . It has anti-nociceptive , analgesic,opioid sparing and sedative properties without respiratory depression.itdecreases sympathetic tone thereby reducing heart rate and blood pressure. Italso increases the stress response to surgery.the dose of dexmedetomidine oftenquoted in the literature is a bolus of 1 mcg/kg/hr over 10 minute followed byinfusion of 0.2-0.7 mcg/kg/hr,but this dose frequently results in brady cardiaand hypotension
Theprimary aim of the study is to evaluate the effect of dexmedetomidine infusionon intraoperative blood loss , haemodynamic changes and anaestheticrequirements in the patients undergoing elective spine surgery The secondaryaim is to study its effect on intraoperative anesthetic and analgesic requirementsduring the surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Adaptive randomization, such as minimization
- 盲法
- Open Label
入排标准
- 年龄范围
- 19.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients giving consent Elective spinal surgeries only Patients aged >18 years & < 65 years Patients of either sex ASA Grade I & II.
排除标准
- •PREGNANT PATIENTS PATIENTS SUFFERING FROM HYPERTENSION UNCONTROLLED DIABETES MELLITUS MORBID OBESITY COPD SEVERE RENAL, HEPATIC, CARDIAC DYSFUNCTION EMERGENCY SPINE SURGERY HISTORY OF DRUG ABUSE.
结局指标
主要结局
BLOOD LOSS
时间窗: HYPOTENSION - EVERY 30 MINUTES | BLOOD LOSS - EVERY 30 MINUTES | ANALGESIA USE - EVERY 30 MINUTES
HYPOTENSION
时间窗: HYPOTENSION - EVERY 30 MINUTES | BLOOD LOSS - EVERY 30 MINUTES | ANALGESIA USE - EVERY 30 MINUTES
ANALGESIA USE
时间窗: HYPOTENSION - EVERY 30 MINUTES | BLOOD LOSS - EVERY 30 MINUTES | ANALGESIA USE - EVERY 30 MINUTES
次要结局
- ANALGESIA REQUIREMENT(ANALGESIA USE - EVERY 1 HOUR)