Prognosis Stratification for pT4bN0M0 Colorectal Cancer Following Multivisceral Resection: A Multi-institutional Retrospective Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 172
- 试验地点
- 1
- 主要终点
- Cancer specific survival
研究概览
简要总结
The purpose of this study was to identify the prognostic factors of affecting pT4bN0M0 colorectal cancer patients, so as to better stratify the prognostic differences among patients with the same stage.
详细描述
Patients with pT4b stage colorectal cancer (CRC) are a complex and special group due to the diversity of infiltrated organs, patients with the same stage often have different prognosis after multivisceral resection (MVR), some important prognostic factors have not been deeply explored, and additional prognostic factors are needed to improve the survival assessment of these patients. In this study, investigators attempted to evaluate the prognostic factors of pT4bN0M0 colorectal cancer, and then stratify the prognosis of such patients to distinguish the survival differences among different patients.
This study was a multicenter retrospective cohort study based on a multicenter database which contained hospitalization.The prognostic factors of pT4bN0M0 colorectal cancer patients were analyzed, and the prognostic grading system was constructed to accurately stratify the survival of pT4bN0M0 patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patient was pathologically diagnosed as colorectal adenocarcinoma.
- •Patients with pT4bN0M0 colorectal cancer.
- •Patients with R0 resection.
排除标准
- •Patients with distant metastasis.
- •Patients with R1 or R2 resection.
- •Patients with lymph node metastasis
- •Recurrent colorectal cancer.
结局指标
主要结局
Cancer specific survival
时间窗: The endpoint of the cancer specific survival assessment is the patient death due to cancer. Follow-up time is up to 72 months.
Cancer specific survival is defined as the time from the diagnosis to death due to cancer progression, which was measured in months.
Overall survival
时间窗: The endpoint of the overall survival assessment is the last follow-up or patient death. Follow-up time is up to 72 months.
Overall survival is defined as the time from the surgery to death or last follow-up, regardless of disease recurrence, which was measured in months.
次要结局
未报告次要终点
研究者
Jianqiang Tang
Associate professor
Cancer Institute and Hospital, Chinese Academy of Medical Sciences