Exploring the Influence of Elevated Indoor CO2 Levels on Allergic Skin Disorders
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 主要终点
- Skin barrier evaluation
研究概览
简要总结
The goal of this clinical trial is to investigate the impact of elevated indoor CO2 levels on skin barrier function and inflammation in healthy adults. The main questions it aims to answer are:
How do increased indoor CO2 levels contribute to type 2 inflammation and barrier dysfunction in human skin? What is the demonstrable impact of high CO2 exposure on the human skin barrier and transcriptome? Participants will be exposed to controlled levels of CO2 in either well-ventilated or non-ventilated (closed) bedrooms.
We will evaluate epithelial barrier function by electrical impedance spectroscopy (EIS), collect skin biopsy samples, and investigate the change induced by high indoor CO2 exposure. Healthy adults meeting the inclusion criteria will be included and those with chronic skin conditions, allergies, or recent systemic therapy will be excluded.
Researchers will compare participants exposed to elevated CO2 levels in closed bedrooms with those in well-ventilated bedrooms to determine if skin barrier integrity and transcriptome variations are observed.
详细描述
- Core Message:
Elevated indoor CO2 levels in closed rooms may contribute to skin barrier dysfunction and inflammation. Understanding the impact of increasing CO2 on the skin is essential to public health. 2. Supporting Information:
Atopic dermatitis (AD) affects a significant population, and indoor CO2 levels are rising in the bedroom.
Preliminary studies demonstrate the association between CO2 exposure and skin barrier dysfunction.
Skin barrier functions can be assessed by electrical impedance spectroscopy (EIS) in vivo. 3. Key Points:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The study population will consist of healthy adult volunteers;
- •age between18 and 65 years,
- •Generally healthy and able to provide written informed consent.
- •The choice of healthy adult volunteers without pre-existing skin conditions on site or allergies against tested products is justified.
排除标准
- •Severe dermatitis, eczema, psoriasis, or other chronic skin conditions.
- •History of hypersensitivity or allergies to tested product ingredients.
- •Current or recent systemic therapy for a skin condition in the past six months.
- •Pregnant or breastfeeding individuals.
- •Use of investigational drugs or participation in another trial in the last 30 days.
- •History of skin cancer or malignancies in the study area.
- •Significant sunburn, open wounds, or active skin infections in the study area.
- •Any medical condition that, per the investigator, might compromise safety or confound results.
- •Inability to follow study instructions or attend required clinic visits.
- •Gender Balance: To ensure gender balance, efforts will be made to recruit an equal number of male and female participants.
结局指标
主要结局
Skin barrier evaluation
时间窗: before (0 hour) and after 8 hours of sleep in ventilated or closed bedroom.
We will measure skin barrier integrity by electrical impedance spectroscopy
Skin biopsy collection
时间窗: After the electrical impedance measurment at 8 hours
We will collect skin biopsy from the forearm that we measure electrical impedance
次要结局
未报告次要终点