Influence of a Polyphenol-enriched Protein Powder on Exercise-induced Inflammation and Oxidative Stress in Athletes: a Metabolomics Approach
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Metabolomics; change in metabolites over time
研究概览
简要总结
Nutrasorb is a newly developed food product (see www.nutrasorb.com). This study will use the Nutrasorb soy protein product that is matrixed with polyphenols from blueberries and green tea extract, and test for efficacy as a nutritional countermeasure to exercise-induced physiologic stress (i.e., immune dysfunction, inflammation, and oxidative stress) using both traditional and metabolomics-based outcome measures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female endurance athletes; competitive runners or cyclists
- •Capable of exercising for 2.5 h at a high intensity in the lab
- •Ages 18-55
- •Agree to train normally and stay weight stable.
- •Agree to avoid the use of large dose vitamin/mineral supplements
- •Agree to avoid herbs and medications that influence inflammation
排除标准
- •Regularly take supplements or medicines known to effect inflammation.
- •At moderate or high risk for cardiovascular disease.
- •Younger than 18 or older than 55 years of age.
- •No history of competing in long distance running and cycling races.
研究组 & 干预措施
Nutrasorb
Soy protein powder sorbed with polyphenols from blueberries and green tea extract
干预措施: Nutrasorb (Dietary Supplement)
Placebo
Soy protein isolate powder without polyphenols (with food coloring)
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Metabolomics; change in metabolites over time
时间窗: 18-day period; Blood samples collected pre- and post-14 d supplementation, and immediately and 14 h after the third day of running
GC-MS and LC-MS through Metabolon
次要结局
- Change in inflammation(18-day period; Blood samples collected pre- and post-14 d supplementation, and immediately and 14 h after the third day of running)
- Change in oxidative stress(18-day period; Blood samples collected pre- and post-14 d supplementation, and immediately and 14 h after the third day of running)
- Change in immune function(18-day period; Blood samples collected pre- and post-14 d supplementation, and immediately and 14 h after the third day of running)