Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo: A Case-control Study in the United Kingdom, 2009-2020
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 75,771
- 试验地点
- 1
- 主要终点
- Number of New Onset Skin Cancers in the >=65 Age Subgroup
研究概览
简要总结
This study examines melanoma and nonmelanoma skin cancer in people diagnosed with vitiligo compared to matched controls.
详细描述
For the primary analysis, this study examines the risk of melanoma and nonmelanoma skin cancers: squamous cell carcinoma and basal cell carcinoma in people diagnosed with vitiligo. It also examines actinic keratoses. In secondary analysis, this study examines the prevalence of skin cancer in people diagnosed with vitiligo compared to matched controls.
This study also examines whether the susceptibility to melanoma and nonmelanoma skin cancer may vary between different patient subgroups, e.g. ethnicity, those who undergo phototherapy or treatment with the new targeted biologic immunosuppressive therapies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All eligible adult patients (aged ≥ 18) registered with General Practioner (GP) practices contributing data to OPCRD between January 1, 2010 and December 31, 2020, were eligible for inclusion in the study. People diagnosed with vitiligo prior to the study period (prevalent vitiligo) and people newly diagnosed with vitiligo during the study period (incident vitiligo) are included as cases.
排除标准
- •People actively registered with the GP practice at that date without a history of vitiligo require a minimum one-year registration with their GP practice.
结局指标
主要结局
Number of New Onset Skin Cancers in the >=65 Age Subgroup
时间窗: 10 years from the index date
Number of new onset skin cancers assessed prospectively in vitiligo cases and matched controls by those aged \>=65
Number of New Onset Skin Cancers in the White Ethnicity Subgroup
时间窗: 10 years from the index date
Number of new onset skin cancers assessed prospectively in vitiligo cases and matched controls by those of white ethnicity
Number of New Onset Skin Cancers in the Non-white Ethnicity Subgroup
时间窗: 10 years from the index date
Number of new onset skin cancers assessed prospectively in vitiligo cases and matched controls by those of non-white ethnicity
Number of New Onset Skin Cancers in the Most Deprived Subgroup
时间窗: 10 years from the index date
Number of new onset skin cancers assessed prospectively in vitiligo cases and matched controls by those in the most deprived subgroup category
Number of New Onset Skin Cancers in the Least Deprived Subgroup
时间窗: 10 years from the index date
Number of new onset skin cancers assessed prospectively in vitiligo cases and matched controls by those in the least deprived subgroup category
Number of New Onset Skin Cancers in the <45 Age Subgroup
时间窗: 10 years from the index date
Number of new onset skin cancers assessed prospectively in vitiligo cases and matched controls by those aged \<45
Number of New Onset Skin Cancers in the 45-64 Age Subgroup
时间窗: 10 years from the index date
Number of new onset skin cancers assessed prospectively in vitiligo cases and matched controls by those aged 45-64
Number of New Onset Skin Cancer in Adult People Diagnosed With Vitiligo
时间窗: 10 years from the index date
Number of new onset skin cancer assessed prospectively in vitiligo cases and matched controls. The skin cancer outcome comprises of the composite of melanoma and nonmelanoma skin cancers: squamous cell carcinoma and basal cell carcinoma.
Number of New Onset Skin Cancers in the Female Sex Subgroup
时间窗: 10 years from the index date
Number of new onset skin cancers assessed prospectively in female vitiligo cases and matched controls.
Number of New Onset Skin Cancers in the Male Sex Subgroup
时间窗: 10 years from the index date
Number of new onset skin cancers assessed prospectively in male vitiligo cases and matched controls.
次要结局
- Prevalence of Basal Cell Carcinoma Skin Cancer in Adult People Diagnosed With Vitiligo(At index date.)
- Prevalence of Skin Cancer in Adult People Diagnosed With Vitiligo(At index date)
- Number of New Onset Actinic Keratoses in Adult People Diagnosed With Vitiligo(10 years from the index date)
- Prevalence of Melanoma Skin Cancer in Adult People Diagnosed With Vitiligo(At index date.)
- Prevalence of Squamous Cell Carcinoma Skin Cancer in Adult People Diagnosed With Vitiligo(At index date.)
- Prevalence of Actinic Keratoses in Adult People Diagnosed With Vitiligo(At index date.)