ISRCTN12578022
Completed
未知
A randomized, double-blind, controlled trial to evaluate the effect of esketamine on postoperative depressive symptoms in breast cancer patients undergoing modified radical mastectomy (Esketamine in Breast Cancer-Depression Randomized Trial)
The First Affiliated Hospital of University of South China0 sites108 target enrollmentAugust 25, 2024
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Breast cancer with postoperative depressive symptoms
- Sponsor
- The First Affiliated Hospital of University of South China
- Enrollment
- 108
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. HAMD\-17 score between 8 and 24 (mild to severe depressive symptoms)
- •2\. Age range between 18 and 65 years
- •3\. American Society of Anesthesiologists (ASA) physical status classification of I\-II
- •4\. Confirmed diagnosis of breast cancer and planned unilateral radical mastectomy for breast cancer
Exclusion Criteria
- •1\. HAMD\-17 score of greater than 24 or less than 7
- •2\. Other psychiatric disorders (e.g., schizophrenia and bipolar disorder)
- •3\. History of psychiatric disorders prior to the study
- •4\. Patients who have used psychotropic medications or have other serious systemic illnesses (including serious heart, kidney, or liver disease)
- •5\. Contraindication or allergy to the use of esketamine
- •6\. Planned surgery other than radical mastectomy alone (e.g., reconstruction)
Outcomes
Primary Outcomes
Not specified
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