Study to compare the effect of a synthetic bone graft material alone and in combination with a component of blood (platelet membrane) in bony defects associated with gum diseases

Recruiting

Brief Summary: The periodontal infection results from the subgingival colonization of periodontopathic bacteria. However, subgingival infection can cause anatomic changes in periodontal tissues (i.e., increased probing depth [PD] and intrabony defects) that can produce local conditions that favor recurrence of the disease. Periodontal treatment includes the surgical elimination of anatomic deformities by restoring the lost supporting tissues. Periodontal regeneration refers to the reproduction or reconstitution of a lost or injured part. Osseous grafting and guided tissue regeneration (GTR) are the two techniques with the most histologic documentation of periodontal regeneration in intrabony defect. Various growth factors have been shown to accelerate the healing process. Platelet also releases growth factors which are natural biological mediators that regulate crucial cellular events involved in tissue repair. So platelet rich fibrin will provide growth factors and additionally the simplicity of procedure will help in treatment of intrabony defects. The aim of the study is to evaluate the efficacy of the bone graft material (Beta-tricalcium phosphate + hydroxyapatite) alone and in combination with Platelet Rich Fibrin membrane in treatment of intrabony defects. xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /

Recruitment & Eligibility

Inclusion Criteria

Intrabony defects in maxillary and mandibular arch 2.
Patients with two or more intrabony defects (Isolateral/contralateral) as well as isolated intrabony defects 3.
Intrabony defects (IBD)greater than or equal to 3 mm deep [distance between alveolar crest and base of the defect on intraoral periapical radiograph (IOPA)] along with an interproximal probing depth (PD) greater than or equal to 5 mm following phase I therapy 4.
Absence of overt clinical inflammation at the time of surgery 5.
Adequate amounts of interdental soft tissues 6.
Absence of any local anatomical limitations 7.
Patient willing for surgery and ready to give written consent.

Exclusion Criteria

1.Patients with systemic illness known to affect the outcomes of periodontal therapy, such as diabetes mellitus, cardiac diseases, platelet count less than 200,000/mm cube, or immunocompromised (e.g., HIV individuals) patients taking medications, such as corticosteroids.
2.Individuals allergic to medications 3.Pregnant or lactating women 4.Patients using tobacco in any form 5.Individuals with unacceptable oral hygiene (plaque index [PI] greater than 1.5).

Primary Outcome Measures

Name	Time	Method
Probing depth, Clinical attachment level	4 months

Secondary Outcome Measures

Name	Time	Method
Radiographic evaluation with the help of image analysis software	4 months

Locations (1): Department of Periodontology and Oral Implantology, S M B T Dental College,
🇮🇳
Ahmadnagar, MAHARASHTRA, India
Department of Periodontology and Oral Implantology, S M B T Dental College,
🇮🇳Ahmadnagar, MAHARASHTRA, India
Pooja S Malpani
Principal investigator
9960746376
poojame2050@hotmail.com