Surgical and Non-surgical Treatment of Peri-implantitis: Multi-center Randomised Controlled Trial of 12-months Follow-up
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Peri-implantitis
- Sponsor
- Federal University of Rio Grande do Sul
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Pocket depth reduction
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
This study will compare surgical and non surgical treatments of peri-implantitis. Peri-implantitis is an inflammation around dental implants that can lead to the loss of the implant over time if no treatment is established. The signs of peri-implantitis included bleeding of the gingiva, swelling and redness. Most of times there is no pain. Patients presenting with these characteristics will be included at random to one of the treatment groups. Those allocated to the non-surgical group will received implant cleansing after local anesthesia using adequate instruments. In the surgical group, patients will be submitted to a surgical procedure around the implant for visualization and cleansing also after local anesthesia. All patients will be followed over a 12-month period. The hypothesis is that surgical treatment is better than non-surgical treatment regarding clinical, radiographic, microbiological, and immunological.characteristics.
Investigators
Alex Nogueira Haas
Associate Professor
Federal University of Rio Grande do Sul
Eligibility Criteria
Inclusion Criteria
- •Individuals with at least one dental implant with peri-implantitits
- •Individuals with good general health conditions;
- •Individuals presenting at least 10 natural teeth;
- •Individuals with no signs of active periodontitis
Exclusion Criteria
- •Individuals who received periodontal treatment in the last three months
- •Systemic condition that interferes with treatment such as diabetes
- •Individuals who are taking or have taken antibiotics or anti-inflammatory medication
Outcomes
Primary Outcomes
Pocket depth reduction
Time Frame: 12 months
Secondary Outcomes
- Clinical attachment level changes(12 months)
- Gingival crevicular fluid immune-inflammatory biomarkers(12 motnhs)
- Bleeding on probing(12 months)
- Serum biomarkers of inflammation(12 months)
- Alveolar bone level changes(12 months)
- Subgingival microbiota changes(12 months)