Exploring the human gut microbiome, metabolome and alpha synuclein in health and Parkinsonâ??s disease (PD) â?? a window to the gut microbiota-brain axis alterations in PD

Indian Council of Medical Research ICMR0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•Inclusion criteria for PD: (1) Diagnosis of PD (according to UKPDS Brain Bank Diagnostic criteria) (2) Early stages of the disease (Hoehn and Yahr stage 2.5 or lesser) (3) Age more than 60 years
•Inclusion-criteria for healthy volunteer controls : (1) Age and gender matched to PD patients (2) Normal neurological examination

•Exclusion criteria for PD patients: (1) Any other significant neurologic disease, history of alcohol/substance dependence, major psychiatric disorders (including major depression), or any other significant medical illness. (2) Atypical or secondary Parkinsonism. (3) The use of systemic (oral or I/V) antibiotics in the previous 3 months (4) Corticosteroid use (oral, IV, nasal, or inhaled) or use of immune stimulating medications, immunosuppressive agents or large doses of commercial probiotics (5) Major dietary change during previous month (defined as eliminating or significantly increasing a major food group) (6) major GI tract surgery in past 5 years (with the exception of cholecystectomy and appendectomy) (7) Bowel resection at any time (7) active uncontrolled GI disorders or diseases including inflammatory bowel disease (IBD), indeterminate colitis, irritable bowel syndrome (IBS), persistent, infectious gastroenteritis, colitis or gastritis, persistent or chronic diarrhea of unknown etiology
•Exclusion-Criteria for Healthy volunteers: Same as for PD patients

发起方

Indian Council of Medical Research ICMR